Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner–Wadsworth–Emmons olefination/cyclisation

Calum William Muir, Alan Kennedy, Joanna Redmond, Allan Watson

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


4H-Quinolizin-4-ones are a unique class of heterocycle with valuable physicochemical properties and which are emerging as key pharmacophores for a range of biological targets. A tandem Horner–Wadsworth–Emmons olefination/cyclisation method has been developed to allow facile access to substituted 4H-quinolizin-4-ones encoded with a range of functional groups
Original languageEnglish
Pages (from-to)3337-3340
Number of pages4
JournalOrganic & Biomolecular Chemistry
Issue number20
Publication statusPublished - 28 May 2013


  • synthesis
  • functionalised 4H-quinolizin-4-ones
  • tandem
  • horner-wadsworth-emmons
  • olefination/cyclisation
  • facile access
  • key pharmacophores


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