Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner–Wadsworth–Emmons olefination/cyclisation

Calum William Muir; Alan Kennedy; Joanna Redmond; Allan Watson

doi:10.1039/c3ob40578h

Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner–Wadsworth–Emmons olefination/cyclisation

Calum William Muir, Alan Kennedy, Joanna Redmond, Allan Watson

School of Chemistry

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

4H-Quinolizin-4-ones are a unique class of heterocycle with valuable physicochemical properties and which are emerging as key pharmacophores for a range of biological targets. A tandem Horner–Wadsworth–Emmons olefination/cyclisation method has been developed to allow facile access to substituted 4H-quinolizin-4-ones encoded with a range of functional groups

Original language	English
Pages (from-to)	3337-3340
Number of pages	4
Journal	Organic & Biomolecular Chemistry
Volume	11
Issue number	20
DOIs	https://doi.org/10.1039/c3ob40578h
Publication status	Published - 28 May 2013

Keywords

synthesis
functionalised 4H-quinolizin-4-ones
tandem
horner-wadsworth-emmons
olefination/cyclisation
facile access
key pharmacophores

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10.1039/c3ob40578h

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abstract = "4H-Quinolizin-4-ones are a unique class of heterocycle with valuable physicochemical properties and which are emerging as key pharmacophores for a range of biological targets. A tandem Horner–Wadsworth–Emmons olefination/cyclisation method has been developed to allow facile access to substituted 4H-quinolizin-4-ones encoded with a range of functional groups",

keywords = "synthesis, functionalised 4H-quinolizin-4-ones, tandem, horner-wadsworth-emmons, olefination/cyclisation, facile access, key pharmacophores",

author = "Muir, {Calum William} and Alan Kennedy and Joanna Redmond and Allan Watson",

year = "2013",

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T1 - Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner–Wadsworth–Emmons olefination/cyclisation

AU - Muir, Calum William

AU - Kennedy, Alan

AU - Redmond, Joanna

AU - Watson, Allan

PY - 2013/5/28

Y1 - 2013/5/28

N2 - 4H-Quinolizin-4-ones are a unique class of heterocycle with valuable physicochemical properties and which are emerging as key pharmacophores for a range of biological targets. A tandem Horner–Wadsworth–Emmons olefination/cyclisation method has been developed to allow facile access to substituted 4H-quinolizin-4-ones encoded with a range of functional groups

AB - 4H-Quinolizin-4-ones are a unique class of heterocycle with valuable physicochemical properties and which are emerging as key pharmacophores for a range of biological targets. A tandem Horner–Wadsworth–Emmons olefination/cyclisation method has been developed to allow facile access to substituted 4H-quinolizin-4-ones encoded with a range of functional groups

KW - synthesis

KW - functionalised 4H-quinolizin-4-ones

KW - tandem

KW - horner-wadsworth-emmons

KW - olefination/cyclisation

KW - facile access

KW - key pharmacophores

U2 - 10.1039/c3ob40578h

DO - 10.1039/c3ob40578h

M3 - Article

SN - 1477-0520

VL - 11

SP - 3337

EP - 3340

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

IS - 20

ER -

Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner–Wadsworth–Emmons olefination/cyclisation

Abstract

Keywords

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