Abstract
An isothiourea-catalyzed Michael addition–lactamization followed by the sulfide oxidation–elimination/N- to O-sulfonyl transfer sequence for the formation of 2,3,5- and 2,3-substituted pyridine 6-tosylates from (phenylthio)acetic acids and α,β-unsaturated ketimines is described. Incorporation of the valuable 2-sulfonate group allows derivatization to a range of di-, tri-, and tetrasubstituted pyridines.
Original language | English |
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Pages (from-to) | 6496-6499 |
Journal | Organic Letters |
Volume | 16 |
Issue number | 24 |
Early online date | 8 Dec 2014 |
DOIs | |
Publication status | Published - 19 Dec 2014 |