TY - JOUR
T1 - Synthesis of chiral epsilon-lactones in a two-enzyme system of cyclohexanone mono-oxygenase and formate dehydrogenase with integrated bubble-free aeration
AU - Rissom, S
AU - Schwarz-Linek, Ulrich
AU - Vogel, M
AU - Tishkov, VI
AU - Kragl, U
PY - 1997/8/14
Y1 - 1997/8/14
N2 - A two-enzyme system consisting of a cyclohexanone mono-oxygenase from Acinetobacter NCIMB 9871 and a protein-engineered formate dehydrogenase for the regeneration of the cofactor NADPH was used for the synthesis of chiral epsilon-lactones. 4-Methylcyclohexanone was used as the model substrate yielding (S)-(-)-5-methyl-oxepane-2-one with high chemical and enantiomeric purity. Syntheses were carried out in a repetitive-batch reactor with integrated bubble-free aeration by means of a thin-walled silicon tube. (C) 1997 Elsevier Science Ltd.
AB - A two-enzyme system consisting of a cyclohexanone mono-oxygenase from Acinetobacter NCIMB 9871 and a protein-engineered formate dehydrogenase for the regeneration of the cofactor NADPH was used for the synthesis of chiral epsilon-lactones. 4-Methylcyclohexanone was used as the model substrate yielding (S)-(-)-5-methyl-oxepane-2-one with high chemical and enantiomeric purity. Syntheses were carried out in a repetitive-batch reactor with integrated bubble-free aeration by means of a thin-walled silicon tube. (C) 1997 Elsevier Science Ltd.
KW - BAEYER-VILLIGER OXIDATION
KW - REGIOSELECTIVITY
KW - KETONES
UR - http://www.scopus.com/inward/record.url?scp=0030738089&partnerID=8YFLogxK
U2 - 10.1016/S0957-4166(97)00311-X
DO - 10.1016/S0957-4166(97)00311-X
M3 - Article
VL - 8
SP - 2523
EP - 2526
JO - Tetrahedron: Asymmetry
JF - Tetrahedron: Asymmetry
IS - 15
ER -