Synthesis of biaryl, arylamine and aryl ketone compounds using a commercially available air- and moisture-stable palladium catalyst

N  Marion; O  Navarro; R A  Kelly; Steven Patrick Nolan

doi:10.1055/s-2003-42402

Synthesis of biaryl, arylamine and aryl ketone compounds using a commercially available air- and moisture-stable palladium catalyst

N Marion, O Navarro, R A Kelly, Steven Patrick Nolan

Research output: Contribution to journal › Article › peer-review

Abstract

A commercially available palladium complex bearing a N-heterocyclic carbene (NHC) was used in gram-scale synthesis of three compounds, a biaryl, an arylamine and an aryl ketone. The syntheses were performed in catalytic fashion using a Suzuki-Miyaura, a Buchwald-Hartwig and a ketone arylation reaction protocol. These three reactions were carried out using the same palladium pre-catalyst.

Original language	English
Pages (from-to)	2590-2592
Number of pages	3
Journal	Synthesis
Issue number	16
DOIs	https://doi.org/10.1055/s-2003-42402
Publication status	Published - 14 Nov 2003

Keywords

N-heterocyclic carbene
palladium
cross-coupling
ketone arylation
Suzuki-Miyaura coupling
aryl-amination
CROSS-COUPLING REACTIONS
N-HETEROCYCLIC CARBENES
ALPHA-ARYLATION
(NHC)PD(ALLYL)CL NHC
COMPLEXES BEARING
LIGANDS
CHLORIDES
REACTIVITY
AMINATION
BROMIDES

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title = "Synthesis of biaryl, arylamine and aryl ketone compounds using a commercially available air- and moisture-stable palladium catalyst",

abstract = "A commercially available palladium complex bearing a N-heterocyclic carbene (NHC) was used in gram-scale synthesis of three compounds, a biaryl, an arylamine and an aryl ketone. The syntheses were performed in catalytic fashion using a Suzuki-Miyaura, a Buchwald-Hartwig and a ketone arylation reaction protocol. These three reactions were carried out using the same palladium pre-catalyst.",

keywords = "N-heterocyclic carbene, palladium, cross-coupling, ketone arylation, Suzuki-Miyaura coupling, aryl-amination, CROSS-COUPLING REACTIONS, N-HETEROCYCLIC CARBENES, ALPHA-ARYLATION, (NHC)PD(ALLYL)CL NHC, COMPLEXES BEARING, LIGANDS, CHLORIDES, REACTIVITY, AMINATION, BROMIDES",

author = "N Marion and O Navarro and Kelly, \{R A\} and Nolan, \{Steven Patrick\}",

year = "2003",

month = nov,

day = "14",

doi = "10.1055/s-2003-42402",

language = "English",

pages = "2590--2592",

journal = "Synthesis",

issn = "0039-7881",

publisher = "Georg Thieme Verlag",

number = "16",

}

TY - JOUR

T1 - Synthesis of biaryl, arylamine and aryl ketone compounds using a commercially available air- and moisture-stable palladium catalyst

AU - Marion, N

AU - Navarro, O

AU - Kelly, R A

AU - Nolan, Steven Patrick

PY - 2003/11/14

Y1 - 2003/11/14

N2 - A commercially available palladium complex bearing a N-heterocyclic carbene (NHC) was used in gram-scale synthesis of three compounds, a biaryl, an arylamine and an aryl ketone. The syntheses were performed in catalytic fashion using a Suzuki-Miyaura, a Buchwald-Hartwig and a ketone arylation reaction protocol. These three reactions were carried out using the same palladium pre-catalyst.

AB - A commercially available palladium complex bearing a N-heterocyclic carbene (NHC) was used in gram-scale synthesis of three compounds, a biaryl, an arylamine and an aryl ketone. The syntheses were performed in catalytic fashion using a Suzuki-Miyaura, a Buchwald-Hartwig and a ketone arylation reaction protocol. These three reactions were carried out using the same palladium pre-catalyst.

KW - N-heterocyclic carbene

KW - palladium

KW - cross-coupling

KW - ketone arylation

KW - Suzuki-Miyaura coupling

KW - aryl-amination

KW - CROSS-COUPLING REACTIONS

KW - N-HETEROCYCLIC CARBENES

KW - ALPHA-ARYLATION

KW - (NHC)PD(ALLYL)CL NHC

KW - COMPLEXES BEARING

KW - LIGANDS

KW - CHLORIDES

KW - REACTIVITY

KW - AMINATION

KW - BROMIDES

UR - https://www.scopus.com/pages/publications/0345305249

U2 - 10.1055/s-2003-42402

DO - 10.1055/s-2003-42402

M3 - Article

SN - 0039-7881

SP - 2590

EP - 2592

JO - Synthesis

JF - Synthesis

IS - 16

ER -

Synthesis of biaryl, arylamine and aryl ketone compounds using a commercially available air- and moisture-stable palladium catalyst

Abstract

Keywords

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