Synthesis of a cell-permeable analogue of a glycosylphosphatidylinositol (GPI) intermediate that is toxic to the living bloodstream form of Trypanosoma brucei

A  Crossman; Terry K Smith; M A J  Ferguson; J S  Brimacombe

doi:10.1016/j.tetlet.2005.08.112

Synthesis of a cell-permeable analogue of a glycosylphosphatidylinositol (GPI) intermediate that is toxic to the living bloodstream form of Trypanosoma brucei

A Crossman, Terry K Smith, M A J Ferguson, J S Brimacombe

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of two cell-permeable analogues related to a GPI intermediate is described for studies with living trypano-somes and human (HeLa) cells. One of the analogues is metabolised by the former GPI pathway and is toxic to the parasite Try-panosoma brucei but not to human cells. (c) 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	7419-7421
Number of pages	3
Journal	Tetrahedron Letters
Volume	46
Issue number	43
DOIs	https://doi.org/10.1016/j.tetlet.2005.08.112
Publication status	Published - 24 Oct 2005

Keywords

Trypanosoma brucei
cell-permeable glycosylphosphatidylinositol (GPI) analogues
African sleeping sickness
bioactivatable acetoxymethyl ester
AFRICAN SLEEPING SICKNESS
BIOSYNTHETIC-PATHWAY
SUBSTRATE-ANALOGS
MEMBRANE ANCHORS
PARASITE
SPECIFICITIES
INHIBITION
ENZYMES
TARGET

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tetlet.2005.08.112

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title = "Synthesis of a cell-permeable analogue of a glycosylphosphatidylinositol (GPI) intermediate that is toxic to the living bloodstream form of Trypanosoma brucei",

abstract = "The synthesis of two cell-permeable analogues related to a GPI intermediate is described for studies with living trypano-somes and human (HeLa) cells. One of the analogues is metabolised by the former GPI pathway and is toxic to the parasite Try-panosoma brucei but not to human cells. (c) 2005 Elsevier Ltd. All rights reserved.",

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author = "A Crossman and Smith, {Terry K} and Ferguson, {M A J} and Brimacombe, {J S}",

year = "2005",

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doi = "10.1016/j.tetlet.2005.08.112",

language = "English",

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journal = "Tetrahedron Letters",

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T1 - Synthesis of a cell-permeable analogue of a glycosylphosphatidylinositol (GPI) intermediate that is toxic to the living bloodstream form of Trypanosoma brucei

AU - Crossman, A

AU - Smith, Terry K

AU - Ferguson, M A J

AU - Brimacombe, J S

PY - 2005/10/24

Y1 - 2005/10/24

N2 - The synthesis of two cell-permeable analogues related to a GPI intermediate is described for studies with living trypano-somes and human (HeLa) cells. One of the analogues is metabolised by the former GPI pathway and is toxic to the parasite Try-panosoma brucei but not to human cells. (c) 2005 Elsevier Ltd. All rights reserved.

AB - The synthesis of two cell-permeable analogues related to a GPI intermediate is described for studies with living trypano-somes and human (HeLa) cells. One of the analogues is metabolised by the former GPI pathway and is toxic to the parasite Try-panosoma brucei but not to human cells. (c) 2005 Elsevier Ltd. All rights reserved.

KW - Trypanosoma brucei

KW - cell-permeable glycosylphosphatidylinositol (GPI) analogues

KW - African sleeping sickness

KW - bioactivatable acetoxymethyl ester

KW - AFRICAN SLEEPING SICKNESS

KW - BIOSYNTHETIC-PATHWAY

KW - SUBSTRATE-ANALOGS

KW - MEMBRANE ANCHORS

KW - PARASITE

KW - SPECIFICITIES

KW - INHIBITION

KW - ENZYMES

KW - TARGET

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U2 - 10.1016/j.tetlet.2005.08.112

DO - 10.1016/j.tetlet.2005.08.112

M3 - Article

SN - 0040-4039

VL - 46

SP - 7419

EP - 7421

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 43

ER -

Synthesis of a cell-permeable analogue of a glycosylphosphatidylinositol (GPI) intermediate that is toxic to the living bloodstream form of Trypanosoma brucei

Abstract

Keywords

UN SDGs

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