Synthesis of a 2-(2-Trifluoroethoxyphenyl)oxazoline

R Alan Aitken; Andrew David Harper

doi:10.3390/M1989

Synthesis of a 2-(2-Trifluoroethoxyphenyl)oxazoline

R Alan Aitken, Andrew David Harper

Research output: Contribution to journal › Article › peer-review

Abstract

The title compound has been prepared in four steps starting from ethyl 2-fluorobenzoate. The final product as well as the intermediates are fully characterised by spectroscopic methods with the ¹H and ¹³C NMR spectra featuring coupling to ¹⁹F being particularly informative.

Original language	English
Article number	M1989
Number of pages	5
Journal	Molbank
Volume	2025
Issue number	2
DOIs	https://doi.org/10.3390/M1989
Publication status	Published - 2 Apr 2025

Keywords

oxazolines
NMR spectra
19F coupling
trifluoroethoxy compounds

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10.3390/M1989Licence: CC BY

Aitken_2025_Molbank_Synthesis-2_CCBY
Copyright: © 2025 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Originally published by MDPI at https://doi.org/10.3390/M1989.
Final published version, 335 KBLicence: CC BY

Synthesis of a 2-(2-Trifluoroethoxyphenyl)oxazoline (dataset)
Aitken, R. A. (Creator) & Harper, A. D. (Creator), University of St Andrews, 30 Apr 2025
DOI: 10.17630/a2165975-3542-44ed-aa69-72f767b1877c
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title = "Synthesis of a 2-(2-Trifluoroethoxyphenyl)oxazoline",

abstract = "The title compound has been prepared in four steps starting from ethyl 2-fluorobenzoate. The final product as well as the intermediates are fully characterised by spectroscopic methods with the 1H and 13C NMR spectra featuring coupling to 19F being particularly informative.",

keywords = "oxazolines, NMR spectra, 19F coupling, trifluoroethoxy compounds",

author = "Aitken, {R Alan} and Harper, {Andrew David}",

note = "Funding: The study funded by EPSRC (UK) for a DTA studentship to ADH (Grant EP/L505079/1) and the EPSRC UK National Mass Spectrometry Facility at Swansea University.",

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AU - Aitken, R Alan

AU - Harper, Andrew David

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Y1 - 2025/4/2

N2 - The title compound has been prepared in four steps starting from ethyl 2-fluorobenzoate. The final product as well as the intermediates are fully characterised by spectroscopic methods with the 1H and 13C NMR spectra featuring coupling to 19F being particularly informative.

AB - The title compound has been prepared in four steps starting from ethyl 2-fluorobenzoate. The final product as well as the intermediates are fully characterised by spectroscopic methods with the 1H and 13C NMR spectra featuring coupling to 19F being particularly informative.

KW - oxazolines

KW - NMR spectra

KW - 19F coupling

KW - trifluoroethoxy compounds

U2 - 10.3390/M1989

DO - 10.3390/M1989

M3 - Article

SN - 1422-8599

VL - 2025

JO - Molbank

JF - Molbank

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ER -

Synthesis of a 2-(2-Trifluoroethoxyphenyl)oxazoline

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Synthesis of a 2-(2-Trifluoroethoxyphenyl)oxazoline (dataset)

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