Synthesis of 8-substituted bicyclo[3.2.1]octane-6-carboxylic acids and anti-convulsant properties of the corresponding amides

J A  Miller; J  Harris; A A  Miller; G M  Ullah; G M  Welsh

doi:10.1016/j.tetlet.2004.04.007

Synthesis of 8-substituted bicyclo[3.2.1]octane-6-carboxylic acids and anti-convulsant properties of the corresponding amides

J A Miller, J Harris, A A Miller, G M Ullah, G M Welsh

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Novel 8-substituted bicyclo[3.2.1]octane-6-carboxylic acids have been made via [3+2]cycloaddition to alkyne 2. A number of the corresponding amides are anti-convulsam in mice. (C) 2004 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	4323-4327
Number of pages	5
Journal	Tetrahedron Letters
Volume	45
DOIs	https://doi.org/10.1016/j.tetlet.2004.04.007
Publication status	Published - 24 May 2004

Keywords

[3+2]cycloaddition
bicyclo[3.2.1]octane-6-carboxylic acids/amides
anti-convulsant activity
STEREOSELECTIVE TOTAL SYNTHESIS
YLANGO SESQUITERPENOIDS
ACPD
(3+2)CYCLOADDITION
INHIBITORS
ANALOGS
SYSTEM
SERIES
COPA

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10.1016/j.tetlet.2004.04.007

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title = "Synthesis of 8-substituted bicyclo[3.2.1]octane-6-carboxylic acids and anti-convulsant properties of the corresponding amides",

abstract = "Novel 8-substituted bicyclo[3.2.1]octane-6-carboxylic acids have been made via [3+2]cycloaddition to alkyne 2. A number of the corresponding amides are anti-convulsam in mice. (C) 2004 Elsevier Ltd. All rights reserved.",

keywords = "[3+2]cycloaddition, bicyclo[3.2.1]octane-6-carboxylic acids/amides, anti-convulsant activity, STEREOSELECTIVE TOTAL SYNTHESIS, YLANGO SESQUITERPENOIDS, ACPD, (3+2)CYCLOADDITION, INHIBITORS, ANALOGS, SYSTEM, SERIES, COPA",

author = "Miller, {J A} and J Harris and Miller, {A A} and Ullah, {G M} and Welsh, {G M}",

year = "2004",

month = may,

day = "24",

doi = "10.1016/j.tetlet.2004.04.007",

language = "English",

volume = "45",

pages = "4323--4327",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

TY - JOUR

T1 - Synthesis of 8-substituted bicyclo[3.2.1]octane-6-carboxylic acids and anti-convulsant properties of the corresponding amides

AU - Miller, J A

AU - Harris, J

AU - Miller, A A

AU - Ullah, G M

AU - Welsh, G M

PY - 2004/5/24

Y1 - 2004/5/24

N2 - Novel 8-substituted bicyclo[3.2.1]octane-6-carboxylic acids have been made via [3+2]cycloaddition to alkyne 2. A number of the corresponding amides are anti-convulsam in mice. (C) 2004 Elsevier Ltd. All rights reserved.

AB - Novel 8-substituted bicyclo[3.2.1]octane-6-carboxylic acids have been made via [3+2]cycloaddition to alkyne 2. A number of the corresponding amides are anti-convulsam in mice. (C) 2004 Elsevier Ltd. All rights reserved.

KW - [3+2]cycloaddition

KW - bicyclo[3.2.1]octane-6-carboxylic acids/amides

KW - anti-convulsant activity

KW - STEREOSELECTIVE TOTAL SYNTHESIS

KW - YLANGO SESQUITERPENOIDS

KW - ACPD

KW - (3+2)CYCLOADDITION

KW - INHIBITORS

KW - ANALOGS

KW - SYSTEM

KW - SERIES

KW - COPA

U2 - 10.1016/j.tetlet.2004.04.007

DO - 10.1016/j.tetlet.2004.04.007

M3 - Article

SN - 0040-4039

VL - 45

SP - 4323

EP - 4327

JO - Tetrahedron Letters

JF - Tetrahedron Letters

ER -

Synthesis of 8-substituted bicyclo[3.2.1]octane-6-carboxylic acids and anti-convulsant properties of the corresponding amides

Abstract

Keywords

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