Synthesis of [4-13C] - Isoflavonoid Phytoestrogens

Nigel Peter Botting; JL Whalley; MF Oldfield

Synthesis of [4-¹³C] - Isoflavonoid Phytoestrogens

Nigel Peter Botting, JL Whalley, MF Oldfield

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Abstract

Efficient syntheses are described for C-13-labelled derivatives of the isoflavonoid phytoestrogens, genistein, biochanin A, daidzein and formononetin, for use in metabolic studies. The synthetic procedure employs C-13-labelled cyanide as the source of the label to produce the isoflavones with a single C-13 atom at the C-4 position. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	455-460
Number of pages	6
Journal	Tetrahedron
Volume	56
Publication status	Published - 14 Jan 2000

Keywords

isoflavones
labelling
antitumour compounds
plants

Cite this

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title = "Synthesis of [4-13C] - Isoflavonoid Phytoestrogens",

abstract = "Efficient syntheses are described for C-13-labelled derivatives of the isoflavonoid phytoestrogens, genistein, biochanin A, daidzein and formononetin, for use in metabolic studies. The synthetic procedure employs C-13-labelled cyanide as the source of the label to produce the isoflavones with a single C-13 atom at the C-4 position. (C) 2000 Elsevier Science Ltd. All rights reserved.",

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AU - Botting, Nigel Peter

AU - Whalley, JL

AU - Oldfield, MF

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Y1 - 2000/1/14

N2 - Efficient syntheses are described for C-13-labelled derivatives of the isoflavonoid phytoestrogens, genistein, biochanin A, daidzein and formononetin, for use in metabolic studies. The synthetic procedure employs C-13-labelled cyanide as the source of the label to produce the isoflavones with a single C-13 atom at the C-4 position. (C) 2000 Elsevier Science Ltd. All rights reserved.

AB - Efficient syntheses are described for C-13-labelled derivatives of the isoflavonoid phytoestrogens, genistein, biochanin A, daidzein and formononetin, for use in metabolic studies. The synthetic procedure employs C-13-labelled cyanide as the source of the label to produce the isoflavones with a single C-13 atom at the C-4 position. (C) 2000 Elsevier Science Ltd. All rights reserved.

KW - isoflavones

KW - labelling

KW - antitumour compounds

KW - plants

UR - http://www.scopus.com/inward/record.url?scp=0034645759&partnerID=8YFLogxK

M3 - Article

SN - 0040-4020

VL - 56

SP - 455

EP - 460

JO - Tetrahedron

JF - Tetrahedron

ER -

Synthesis of [4-¹³C] - Isoflavonoid Phytoestrogens

Abstract

Keywords

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