Synthesis of [4-13C] - Isoflavonoid Phytoestrogens

Nigel Peter Botting, JL Whalley, MF Oldfield

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Efficient syntheses are described for C-13-labelled derivatives of the isoflavonoid phytoestrogens, genistein, biochanin A, daidzein and formononetin, for use in metabolic studies. The synthetic procedure employs C-13-labelled cyanide as the source of the label to produce the isoflavones with a single C-13 atom at the C-4 position. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)455-460
Number of pages6
JournalTetrahedron
Volume56
Publication statusPublished - 14 Jan 2000

Keywords

  • isoflavones
  • labelling
  • antitumour compounds
  • plants

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