Synthesis of [3,4,8-13C3]daidzein

Mark F Oldfield, Lirong Chen, Nigel Peter Botting

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

The biological effects of the soy isoflavones have attracted considerable interest in recent years leading to numerous studies on dietary intake and epidemiology. Such studies require accurate and reproducible analytical methods. Herein we report the first synthesis of a multiply, C-13-labelled daidzein derivative, [3,4,8-C-13(3)]daidzein, which has been employed as an internal standard in LC-MS and GC-MS analysis. The synthesis includes an improved three-step method for the synthesis of [2-C-13]resorcinol as one building block. (C) 2003 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1887-1893
Number of pages7
JournalTetrahedron
Volume60
Issue number8
DOIs
Publication statusPublished - 16 Feb 2004

Keywords

  • daidzein
  • isoflavones
  • phytoestrogens
  • C-13-labelling
  • TIME-RESOLVED FLUOROIMMUNOASSAY
  • ELECTROSPRAY MASS-SPECTROMETRY
  • ISOTOPE-DILUTION
  • SOY ISOFLAVONES
  • LIQUID-CHROMATOGRAPHY
  • HUMAN URINE
  • PHYTO-ESTROGENS
  • HUMAN HEALTH
  • PHYTOESTROGENS
  • GENISTEIN

Fingerprint

Dive into the research topics of 'Synthesis of [3,4,8-13C3]daidzein'. Together they form a unique fingerprint.

Cite this