Synthesis of 3 '-, 4 '- and 6 '-deoxy and other analogues of D-glucosaminylphosphatidylinositol

C N  Borissow; Terry K Smith; M A J  Ferguson; J S  Brimacombe

Synthesis of 3 '-, 4 '- and 6 '-deoxy and other analogues of D-glucosaminylphosphatidylinositol

C N Borissow, Terry K Smith, M A J Ferguson, J S Brimacombe

Research output: Contribution to journal › Article › peer-review

Abstract

Deoxy and other analogues of D-glucosaminylphosphatidylinositol 1 have been synthesised and tested as substrates or inhibitors of a de-N-acetylase and mannosyltransferase (MT-1) involved in the biosynthesis of the glycosylphosphatidylinositol (GPI) membrane anchor of the parasite Trypanosoma brucei. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	121-123
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	1
Publication status	Published - 1 Jan 2001

Keywords

glycosylphosphatidylinositol (GPI) membrane anchors
D-glucosaminylphosphatidylinositol analogues
GPI biosynthesis
BIOSYNTHETIC-PATHWAY
MEMBRANE ANCHORS

Cite this

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abstract = "Deoxy and other analogues of D-glucosaminylphosphatidylinositol 1 have been synthesised and tested as substrates or inhibitors of a de-N-acetylase and mannosyltransferase (MT-1) involved in the biosynthesis of the glycosylphosphatidylinositol (GPI) membrane anchor of the parasite Trypanosoma brucei. (C) 2000 Elsevier Science Ltd. All rights reserved.",

keywords = "glycosylphosphatidylinositol (GPI) membrane anchors, D-glucosaminylphosphatidylinositol analogues, GPI biosynthesis, BIOSYNTHETIC-PATHWAY, MEMBRANE ANCHORS",

author = "Borissow, \{C N\} and Smith, \{Terry K\} and Ferguson, \{M A J\} and Brimacombe, \{J S\}",

year = "2001",

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T1 - Synthesis of 3 '-, 4 '- and 6 '-deoxy and other analogues of D-glucosaminylphosphatidylinositol

AU - Borissow, C N

AU - Smith, Terry K

AU - Ferguson, M A J

AU - Brimacombe, J S

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Deoxy and other analogues of D-glucosaminylphosphatidylinositol 1 have been synthesised and tested as substrates or inhibitors of a de-N-acetylase and mannosyltransferase (MT-1) involved in the biosynthesis of the glycosylphosphatidylinositol (GPI) membrane anchor of the parasite Trypanosoma brucei. (C) 2000 Elsevier Science Ltd. All rights reserved.

AB - Deoxy and other analogues of D-glucosaminylphosphatidylinositol 1 have been synthesised and tested as substrates or inhibitors of a de-N-acetylase and mannosyltransferase (MT-1) involved in the biosynthesis of the glycosylphosphatidylinositol (GPI) membrane anchor of the parasite Trypanosoma brucei. (C) 2000 Elsevier Science Ltd. All rights reserved.

KW - glycosylphosphatidylinositol (GPI) membrane anchors

KW - D-glucosaminylphosphatidylinositol analogues

KW - GPI biosynthesis

KW - BIOSYNTHETIC-PATHWAY

KW - MEMBRANE ANCHORS

UR - https://www.scopus.com/pages/publications/0035185615

M3 - Article

SN - 0040-4039

VL - 42

SP - 121

EP - 123

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 1

ER -

Synthesis of 3 '-, 4 '- and 6 '-deoxy and other analogues of D-glucosaminylphosphatidylinositol

Abstract

Keywords

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