Synthesis of 3 '-, 4 '- and 6 '-deoxy and other analogues of D-glucosaminylphosphatidylinositol

C N Borissow, Terry K Smith, M A J Ferguson, J S Brimacombe

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5 Citations (Scopus)

Abstract

Deoxy and other analogues of D-glucosaminylphosphatidylinositol 1 have been synthesised and tested as substrates or inhibitors of a de-N-acetylase and mannosyltransferase (MT-1) involved in the biosynthesis of the glycosylphosphatidylinositol (GPI) membrane anchor of the parasite Trypanosoma brucei. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)121-123
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number1
Publication statusPublished - 1 Jan 2001

Keywords

  • glycosylphosphatidylinositol (GPI) membrane anchors
  • D-glucosaminylphosphatidylinositol analogues
  • GPI biosynthesis
  • BIOSYNTHETIC-PATHWAY
  • MEMBRANE ANCHORS

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