Synthesis, characterization, X-ray crystallography, and antimicrobial activities of Ni(II) and Cu(II) complexes with a salicylaldehyde-based thiosemicarbazone ligand

Nitis Chandra Saha*, Rajesh Pradhan, Mousumi Das, Nasima Khatun, Debmalya Mitra, Amalesh Samanta, Alexandra M.Z. Slawin, Atish Dipankar Jana, Julia Klanke, Eva Rentschler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A new salicylaldehyde-based ONS tridentate salicylaldehyde-N(4)- diethylthiosemicarbazone (H2SANEt2) has been synthesized and characterized by elemental analyses mass, IR, and 1H NMR spectral parameters. The coordination mode of the synthesized ligand is reported by solid state isolation and physico-chemical identification of Ni(II) and Cu(II) complexes, [Ni(SANEt2)]2 (1) and [Cu(SANEt 2)]2 (2). Both complexes are neutral and oxygen-bridged dinuclear species. The ligand is bideprotonated ONS tridentate in both complexes. IR spectral data indicate that coordination of each metal of the two complexes occurs through phenolic oxygen, azomethine nitrogen, and thiolato sulfur. X-ray crystallographic data of 1 and 2 (both monoclinic, P 21/c) show a MONSO (where M=Ni and Cu) square-planar coordination around each metal. Magnetic studies of 2 show that the two Cu(II) centers are strongly antiferromagnetically coupled via the bridging phenoxo O. All the synthesized compounds were tested for their in vitro antimicrobial activities against pathogenic bacteria. The inhibition power of the complexes was greater than the parent ligand.

Original languageEnglish
Pages (from-to)286-299
Number of pages14
JournalJournal of Coordination Chemistry
Volume67
Issue number2
DOIs
Publication statusPublished - 17 Jan 2014

Keywords

  • Antimicrobial activity
  • Crystal structures
  • Magnetic property
  • Ni Cu-complexes
  • Thiosemicarbazone

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