Synthesis and single crystal structures of substituted-1,3-selenazol-2-amines

Guoxiong Hua; Junyi Du; Alexandra Martha Zoya Slawin; John Derek Woollins

doi:10.3390/molecules22010046

Synthesis and single crystal structures of substituted-1,3-selenazol-2-amines

Guoxiong Hua, Junyi Du, Alexandra Martha Zoya Slawin, John Derek Woollins

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis and X-ray single crystal structures of a series of new 4-substituted-1,3-selenazol-2-amines is reported. The efficient preparation of 4-substituted-1,3-selenazol-2-amines was carried out by two-component cyclization of the selenoureas with equi-molar amounts of α-haloketones. The selenoureas were obtained from the reaction of Woollins’ reagent with cyanamides, followed by hydrolysis with water. All new compounds have been characterized by IR spectroscopy, multi-NMR (1H, 13C, 77Se) spectroscopy, accurate mass measurement and single crystal X-ray structure analysis.

Original language	English
Article number	46
Journal	Molecules
Volume	22
Issue number	1
DOIs	https://doi.org/10.3390/molecules22010046
Publication status	Published - 29 Dec 2016

Keywords

Cyanamides
Woollins’ reagent
Selenoureas
Selenazol-2-amines

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10.3390/molecules22010046Licence: CC BY

molecules-22-00046
Copyright (c) 2016, the authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Final published version, 1.9 MBLicence: CC BY

Cite this

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title = "Synthesis and single crystal structures of substituted-1,3-selenazol-2-amines",

abstract = "The synthesis and X-ray single crystal structures of a series of new 4-substituted-1,3-selenazol-2-amines is reported. The efficient preparation of 4-substituted-1,3-selenazol-2-amines was carried out by two-component cyclization of the selenoureas with equi-molar amounts of α-haloketones. The selenoureas were obtained from the reaction of Woollins{\textquoteright} reagent with cyanamides, followed by hydrolysis with water. All new compounds have been characterized by IR spectroscopy, multi-NMR (1H, 13C, 77Se) spectroscopy, accurate mass measurement and single crystal X-ray structure analysis.",

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AU - Hua, Guoxiong

AU - Du, Junyi

AU - Slawin, Alexandra Martha Zoya

AU - Woollins, John Derek

N1 - This article belongs to the Special Issue Celebrating Two Centuries of Research in Selenium Chemistry: State of the Art and New Prospectives

PY - 2016/12/29

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N2 - The synthesis and X-ray single crystal structures of a series of new 4-substituted-1,3-selenazol-2-amines is reported. The efficient preparation of 4-substituted-1,3-selenazol-2-amines was carried out by two-component cyclization of the selenoureas with equi-molar amounts of α-haloketones. The selenoureas were obtained from the reaction of Woollins’ reagent with cyanamides, followed by hydrolysis with water. All new compounds have been characterized by IR spectroscopy, multi-NMR (1H, 13C, 77Se) spectroscopy, accurate mass measurement and single crystal X-ray structure analysis.

AB - The synthesis and X-ray single crystal structures of a series of new 4-substituted-1,3-selenazol-2-amines is reported. The efficient preparation of 4-substituted-1,3-selenazol-2-amines was carried out by two-component cyclization of the selenoureas with equi-molar amounts of α-haloketones. The selenoureas were obtained from the reaction of Woollins’ reagent with cyanamides, followed by hydrolysis with water. All new compounds have been characterized by IR spectroscopy, multi-NMR (1H, 13C, 77Se) spectroscopy, accurate mass measurement and single crystal X-ray structure analysis.

KW - Cyanamides

KW - Woollins’ reagent

KW - Selenoureas

KW - Selenazol-2-amines

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DO - 10.3390/molecules22010046

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JO - Molecules

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Synthesis and single crystal structures of substituted-1,3-selenazol-2-amines

Abstract

Keywords

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