Synthesis and mode of action of 1-substituted trans-cyclopropane 1,2-dicarboxylic acids: Inhibitors of the methylaspartase reaction

Kamal Badiani, Philip Lightfoot, David Gani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A range of 1-substituted cyclopropane 1,2-dicarboxylic acids are synthesised using short efficient routes and are found to be good to potent inhibitors of 3-methylaspartase; the crystallographically determined absolute stereochemistry and the mode of action of the most potent inhibitor, (1S,2S)-1-methylcyclopropane 1,2-dicarboxylic acid, is consistent with it acting as a transition state analogue for the central substrate deamination reaction catalysed by the enzyme.

Original languageEnglish
Pages (from-to)675-677
Number of pages3
JournalChemical Communications
Issue number5
DOIs
Publication statusPublished - 1 Jan 1996

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