Synthesis and cytotoxic properties of a series of bicyclo[3.2.1]octane alpha-methylene ketones

J A  Miller; G M  Ullah; G M  Welsh; P  Mallon

Synthesis and cytotoxic properties of a series of bicyclo[3.2.1]octane alpha-methylene ketones

J A Miller, G M Ullah, G M Welsh, P Mallon

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The 8-chlorobicyclo[3.2.1]oct-6-ene 3 has been prepared by a [3+2] cycloaddition route, and converted to the bicyclic alpha -methylene ketones 6 and 8-12. some of which showed cytotoxic properties. (C) 2001 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	2729-2731
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Publication status	Published - 2 Apr 2001

Keywords

[3+2] cycloaddition
Hg(II) mediated hydrolysis
alkynyl and vinyl sulphide
bicyclo[3.2.1]octane alpha-methylene ketones
cytotoxicity
TERRECYCLIC ACID-A
ASPERGILLUS-TERREUS
PROSTANOIDS

Cite this

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title = "Synthesis and cytotoxic properties of a series of bicyclo[3.2.1]octane alpha-methylene ketones",

abstract = "The 8-chlorobicyclo[3.2.1]oct-6-ene 3 has been prepared by a [3+2] cycloaddition route, and converted to the bicyclic alpha -methylene ketones 6 and 8-12. some of which showed cytotoxic properties. (C) 2001 Elsevier Science Ltd. All rights reserved.",

keywords = "[3+2] cycloaddition, Hg(II) mediated hydrolysis, alkynyl and vinyl sulphide, bicyclo[3.2.1]octane alpha-methylene ketones, cytotoxicity, TERRECYCLIC ACID-A, ASPERGILLUS-TERREUS, PROSTANOIDS",

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year = "2001",

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language = "English",

volume = "42",

pages = "2729--2731",

journal = "Tetrahedron Letters",

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T1 - Synthesis and cytotoxic properties of a series of bicyclo[3.2.1]octane alpha-methylene ketones

AU - Miller, J A

AU - Ullah, G M

AU - Welsh, G M

AU - Mallon, P

PY - 2001/4/2

Y1 - 2001/4/2

N2 - The 8-chlorobicyclo[3.2.1]oct-6-ene 3 has been prepared by a [3+2] cycloaddition route, and converted to the bicyclic alpha -methylene ketones 6 and 8-12. some of which showed cytotoxic properties. (C) 2001 Elsevier Science Ltd. All rights reserved.

AB - The 8-chlorobicyclo[3.2.1]oct-6-ene 3 has been prepared by a [3+2] cycloaddition route, and converted to the bicyclic alpha -methylene ketones 6 and 8-12. some of which showed cytotoxic properties. (C) 2001 Elsevier Science Ltd. All rights reserved.

KW - [3+2] cycloaddition

KW - Hg(II) mediated hydrolysis

KW - alkynyl and vinyl sulphide

KW - bicyclo[3.2.1]octane alpha-methylene ketones

KW - cytotoxicity

KW - TERRECYCLIC ACID-A

KW - ASPERGILLUS-TERREUS

KW - PROSTANOIDS

UR - https://www.scopus.com/pages/publications/0035795052

M3 - Article

SN - 0040-4039

VL - 42

SP - 2729

EP - 2731

JO - Tetrahedron Letters

JF - Tetrahedron Letters

ER -

Synthesis and cytotoxic properties of a series of bicyclo[3.2.1]octane alpha-methylene ketones

Abstract

Keywords

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