Synthesis and cytotoxic properties of a series of bicyclo[3.2.1]octane alpha-methylene ketones

J A Miller, G M Ullah, G M Welsh, P Mallon

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The 8-chlorobicyclo[3.2.1]oct-6-ene 3 has been prepared by a [3+2] cycloaddition route, and converted to the bicyclic alpha -methylene ketones 6 and 8-12. some of which showed cytotoxic properties. (C) 2001 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)2729-2731
Number of pages3
JournalTetrahedron Letters
Volume42
Publication statusPublished - 2 Apr 2001

Keywords

  • [3+2] cycloaddition
  • Hg(II) mediated hydrolysis
  • alkynyl and vinyl sulphide
  • bicyclo[3.2.1]octane alpha-methylene ketones
  • cytotoxicity
  • TERRECYCLIC ACID-A
  • ASPERGILLUS-TERREUS
  • PROSTANOIDS

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