Synthesis and characterization of gold(I) N-heterocyclic carbene complexes bearing biologically compatible moieties

Pierre de Fremont, Edwin D. Stevens, Melanie D. Eelman, Deryn E. Fogg, Steven Patrick Nolan

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

Two new gold( I) complexes bearing the bulky N-heterocyclic carbene IPr (IPr = bis(2,6-diisopropylphenyl)imidazol- 2-ylidene) and respectively 2,3,4,6-tetra-O-acetyl-1-thio- beta-D-pyranosatothiolato [(IPr)AuTgt (1)] and a saccharin ligand [(IPr) AuSac (2)] have been synthesized in good yield and are fully characterized by NMR spectroscopy and by inertatmosphere MALDI-TOF. These complexes are well-behaved compounds analogous to gold drugs such as Auranofin and Solganol.

Original languageEnglish
Pages (from-to)5824-5828
Number of pages5
JournalOrganometallics
Volume25
Issue number24
DOIs
Publication statusPublished - 20 Nov 2006

Keywords

  • INVIVO ANTITUMOR-ACTIVITY
  • CROSS-COUPLING REACTIONS
  • CRYSTAL-STRUCTURE
  • STRUCTURAL-CHARACTERIZATION
  • COORDINATION-COMPLEXES
  • RHEUMATOID-ARTHRITIS
  • AURANOFIN
  • LIGANDS
  • INVITRO
  • MODELS

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