Synthesis and Biological Evaluation of Phospholane and Dihydrophosphole Analogues of the Glutamate Receptor Agonist AP4

Stuart John Conway; JC Miller; AD Bond; BP Clark; DE Jane

doi:10.1039/b204891d

Synthesis and Biological Evaluation of Phospholane and Dihydrophosphole Analogues of the Glutamate Receptor Agonist AP4

Stuart John Conway, JC Miller, AD Bond, BP Clark, DE Jane

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The syntheses and preliminary pharmacological characterisation of two novel cyclic phosphinic acid-containing amino acids designed as conformationally restricted analogues of the metabotropic glutamate receptor agonist AP4 (1) are reported.

Original language	English
Pages (from-to)	1625-1627
Number of pages	3
Journal	Journal of the Chemical Society, Perkin Transactions 1
Issue number	14
DOIs	https://doi.org/10.1039/b204891d
Publication status	Published - 2002

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@article{b86f270df3c34fbdad06e459ba2639cb,

title = "Synthesis and Biological Evaluation of Phospholane and Dihydrophosphole Analogues of the Glutamate Receptor Agonist AP4",

abstract = "The syntheses and preliminary pharmacological characterisation of two novel cyclic phosphinic acid-containing amino acids designed as conformationally restricted analogues of the metabotropic glutamate receptor agonist AP4 (1) are reported.",

keywords = "ACID",

author = "Conway, \{Stuart John\} and JC Miller and AD Bond and BP Clark and DE Jane",

note = "Address is Department of Pharmacology, University of Bristol",

year = "2002",

doi = "10.1039/b204891d",

language = "English",

pages = "1625--1627",

journal = "Journal of the Chemical Society, Perkin Transactions 1",

issn = "1472-7781",

publisher = "Chemical Society",

number = "14",

}

TY - JOUR

T1 - Synthesis and Biological Evaluation of Phospholane and Dihydrophosphole Analogues of the Glutamate Receptor Agonist AP4

AU - Conway, Stuart John

AU - Miller, JC

AU - Bond, AD

AU - Clark, BP

AU - Jane, DE

N1 - Address is Department of Pharmacology, University of Bristol

PY - 2002

Y1 - 2002

N2 - The syntheses and preliminary pharmacological characterisation of two novel cyclic phosphinic acid-containing amino acids designed as conformationally restricted analogues of the metabotropic glutamate receptor agonist AP4 (1) are reported.

AB - The syntheses and preliminary pharmacological characterisation of two novel cyclic phosphinic acid-containing amino acids designed as conformationally restricted analogues of the metabotropic glutamate receptor agonist AP4 (1) are reported.

KW - ACID

UR - https://www.scopus.com/pages/publications/0035996940

U2 - 10.1039/b204891d

DO - 10.1039/b204891d

M3 - Article

SN - 1472-7781

SP - 1625

EP - 1627

JO - Journal of the Chemical Society, Perkin Transactions 1

JF - Journal of the Chemical Society, Perkin Transactions 1

IS - 14

ER -

Synthesis and Biological Evaluation of Phospholane and Dihydrophosphole Analogues of the Glutamate Receptor Agonist AP4

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