Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA) .1. 6-methyl derivatives

R Alan Aitken; M C  Bibby; J A  Double; R M  Phillips; S K  Sharma

Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA) .1. 6-methyl derivatives

R Alan Aitken, M C Bibby, J A Double, R M Phillips, S K Sharma

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Abstract

A range of 17 derivatives of flavone-8-acetic acid (FAA) with a B-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.

Original language	English
Pages (from-to)	489-497
Number of pages	9
Journal	Archiv der Pharmazie
Volume	329
Issue number	11
Publication status	Published - Nov 1996

Keywords

flavone acetic acid
synthesis
antitumour activity
structure-activity relationships
FLAVONE ACETIC-ACID
KILLER CELL-ACTIVITY
9-OXO-9H-XANTHENE-4-ACETIC ACID
BLOOD-FLOW
AGENTS
COLON
INVIVO
NSC-347512
ANALOGS
MICE

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title = "Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA) .1. 6-methyl derivatives",

abstract = "A range of 17 derivatives of flavone-8-acetic acid (FAA) with a B-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.",

keywords = "flavone acetic acid, synthesis, antitumour activity, structure-activity relationships, FLAVONE ACETIC-ACID, KILLER CELL-ACTIVITY, 9-OXO-9H-XANTHENE-4-ACETIC ACID, BLOOD-FLOW, AGENTS, COLON, INVIVO, NSC-347512, ANALOGS, MICE",

author = "Aitken, \{R Alan\} and Bibby, \{M C\} and Double, \{J A\} and Phillips, \{R M\} and Sharma, \{S K\}",

year = "1996",

month = nov,

language = "English",

volume = "329",

pages = "489--497",

journal = "Archiv der Pharmazie",

issn = "0365-6233",

publisher = "Wiley-VCH, Weinheim",

number = "11",

}

TY - JOUR

T1 - Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA) .1. 6-methyl derivatives

AU - Aitken, R Alan

AU - Bibby, M C

AU - Double, J A

AU - Phillips, R M

AU - Sharma, S K

PY - 1996/11

Y1 - 1996/11

N2 - A range of 17 derivatives of flavone-8-acetic acid (FAA) with a B-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.

AB - A range of 17 derivatives of flavone-8-acetic acid (FAA) with a B-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.

KW - flavone acetic acid

KW - synthesis

KW - antitumour activity

KW - structure-activity relationships

KW - FLAVONE ACETIC-ACID

KW - KILLER CELL-ACTIVITY

KW - 9-OXO-9H-XANTHENE-4-ACETIC ACID

KW - BLOOD-FLOW

KW - AGENTS

KW - COLON

KW - INVIVO

KW - NSC-347512

KW - ANALOGS

KW - MICE

UR - https://www.scopus.com/pages/publications/0029751390

M3 - Article

SN - 0365-6233

VL - 329

SP - 489

EP - 497

JO - Archiv der Pharmazie

JF - Archiv der Pharmazie

IS - 11

ER -

Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA) .1. 6-methyl derivatives

Abstract

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