Synthesis and Antitumour Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 3: 2-Heteroaryl Derivatives

Robert Alan Aitken; MC Bibby; F Bielefeldt; JA Double; AL Laws; A-L Mathieu; RB Ritchie; DW Wilson

doi:10.1002/(SICI)1521-4184(199812)331:12<405::AID-ARDP405>3.3.CO;2-U

Synthesis and Antitumour Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 3: 2-Heteroaryl Derivatives

Robert Alan Aitken, MC Bibby, F Bielefeldt, JA Double, AL Laws, A-L Mathieu, RB Ritchie, DW Wilson

Research output: Contribution to journal › Article › peer-review

Abstract

A range of 14 derivatives of flavone-8-acetic acid (FAA) with a heterocyclic substituent in place of the 7-phenyl group have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. Some of the compounds, notably 2c,d and s, showed significant in vivo activity and these require further studies in order to evaluate their potential for development.

Original language	English
Pages (from-to)	405-411
Number of pages	7
Journal	Archiv der Pharmazie
Volume	331
Issue number	12
DOIs	https://doi.org/10.1002/(SICI)1521-4184(199812)331:12<405::AID-ARDP405>3.3.CO;2-U
Publication status	Published - Dec 1998

Keywords

flavone acetic acid
synthesis
antitumour activity
structure-activity relationships
FLAVONE ACETIC-ACID
CARCINOMA
AGENTS
TUMORS

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10.1002/(SICI)1521-4184(199812)331:12<405::AID-ARDP405>3.3.CO;2-U

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title = "Synthesis and Antitumour Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 3: 2-Heteroaryl Derivatives",

abstract = "A range of 14 derivatives of flavone-8-acetic acid (FAA) with a heterocyclic substituent in place of the 7-phenyl group have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. Some of the compounds, notably 2c,d and s, showed significant in vivo activity and these require further studies in order to evaluate their potential for development.",

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note = "Arch Pharm Pharm Med Chem",

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AU - Aitken, Robert Alan

AU - Bibby, MC

AU - Bielefeldt, F

AU - Double, JA

AU - Laws, AL

AU - Mathieu, A-L

AU - Ritchie, RB

AU - Wilson, DW

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AB - A range of 14 derivatives of flavone-8-acetic acid (FAA) with a heterocyclic substituent in place of the 7-phenyl group have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. Some of the compounds, notably 2c,d and s, showed significant in vivo activity and these require further studies in order to evaluate their potential for development.

KW - flavone acetic acid

KW - synthesis

KW - antitumour activity

KW - structure-activity relationships

KW - FLAVONE ACETIC-ACID

KW - CARCINOMA

KW - AGENTS

KW - TUMORS

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Synthesis and Antitumour Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 3: 2-Heteroaryl Derivatives

Abstract

Keywords

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