Synthesis and Antitumour Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 3: 2-Heteroaryl Derivatives

Robert Alan Aitken, MC Bibby, F Bielefeldt, JA Double, AL Laws, A-L Mathieu, RB Ritchie, DW Wilson

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

A range of 14 derivatives of flavone-8-acetic acid (FAA) with a heterocyclic substituent in place of the 7-phenyl group have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. Some of the compounds, notably 2c,d and s, showed significant in vivo activity and these require further studies in order to evaluate their potential for development.

Original languageEnglish
Pages (from-to)405-411
Number of pages7
JournalArchiv der Pharmazie
Volume331
Issue number12
DOIs
Publication statusPublished - Dec 1998

Keywords

  • flavone acetic acid
  • synthesis
  • antitumour activity
  • structure-activity relationships
  • FLAVONE ACETIC-ACID
  • CARCINOMA
  • AGENTS
  • TUMORS

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