Synthesis and Antitumour Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 4: Variation of the Basic Structure

Robert Alan Aitken, MC Bibby, PA Cooper, JA Double, AL Laws, R.B. Ritchie, DW Wilson

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

A range of 1 1 derivatives of flavone-8-acetic acid (FAA) in which the structure has been substantially altered in different ways have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. The generally poor activity observed shows that the basic structure cannot be altered much without destroying the activity.

Original languageEnglish
Pages (from-to)181-188
Number of pages8
JournalArchiv der Pharmazie
Volume333
Publication statusPublished - Jun 2000

Keywords

  • flavone acetic acid
  • antitumour activity
  • structure-activity relationships
  • FLAVONE ACETIC-ACID
  • 9-OXO-9H-XANTHENE-4-ACETIC ACID
  • AGENTS
  • ANALOGS
  • AGONISTS
  • INVIVO
  • CARCINOMA
  • RECEPTOR
  • POTENT
  • TUMORS

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