Synthesis and Anti-Tumour Activity of 6-Methyl Derivatives of Flavone Acetic Acid (FAA)

R Alan Aitken; M C  BIBBY; J A  DOUBLE; R M  PHILLIPS; S K  SHARMA

Synthesis and Anti-Tumour Activity of 6-Methyl Derivatives of Flavone Acetic Acid (FAA)

R Alan Aitken, M C BIBBY, J A DOUBLE, R M PHILLIPS, S K SHARMA

Research output: Contribution to journal › Article › peer-review

Abstract

A range of 16 derivatives of flavone-8-acetic acid (FAA) with a 6-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.

Original language	English
Pages (from-to)	2313-2316
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	19
Publication status	Published - 6 Oct 1994

Keywords

POTENTIAL ANTITUMOR AGENTS
FLAVONE ACETIC-ACID
9-OXO-9H-XANTHENE-4-ACETIC ACID
COLON
ANALOGS
INVIVO
CARCINOMA
MICE

Cite this

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title = "Synthesis and Anti-Tumour Activity of 6-Methyl Derivatives of Flavone Acetic Acid (FAA)",

abstract = "A range of 16 derivatives of flavone-8-acetic acid (FAA) with a 6-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.",

keywords = "POTENTIAL ANTITUMOR AGENTS, FLAVONE ACETIC-ACID, 9-OXO-9H-XANTHENE-4-ACETIC ACID, COLON, ANALOGS, INVIVO, CARCINOMA, MICE",

author = "Aitken, {R Alan} and BIBBY, {M C} and DOUBLE, {J A} and PHILLIPS, {R M} and SHARMA, {S K}",

year = "1994",

month = oct,

day = "6",

language = "English",

volume = "4",

pages = "2313--2316",

journal = "Bioorganic and Medicinal Chemistry Letters",

publisher = "Elsevier",

number = "19",

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TY - JOUR

T1 - Synthesis and Anti-Tumour Activity of 6-Methyl Derivatives of Flavone Acetic Acid (FAA)

AU - Aitken, R Alan

AU - BIBBY, M C

AU - DOUBLE, J A

AU - PHILLIPS, R M

AU - SHARMA, S K

PY - 1994/10/6

Y1 - 1994/10/6

N2 - A range of 16 derivatives of flavone-8-acetic acid (FAA) with a 6-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.

AB - A range of 16 derivatives of flavone-8-acetic acid (FAA) with a 6-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.

KW - POTENTIAL ANTITUMOR AGENTS

KW - FLAVONE ACETIC-ACID

KW - 9-OXO-9H-XANTHENE-4-ACETIC ACID

KW - COLON

KW - ANALOGS

KW - INVIVO

KW - CARCINOMA

KW - MICE

UR - http://www.scopus.com/inward/record.url?scp=0028128287&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 2313

EP - 2316

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 19

ER -

Synthesis and Anti-Tumour Activity of 6-Methyl Derivatives of Flavone Acetic Acid (FAA)

Abstract

Keywords

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