Syntheses and coordination chemistry of aminomethylphosphine derivatives of adenine

Two aminomethylphosphane derivatives of adenine 9-(2-bis [ (diphenylphosphanyl)methyll amino) ethyl) adenine (La) and 9-(3-{bis[(diphenylphosphanyl)methyl]amino}propyl)-adenine (Lb) were synthesised. Oxidation of La and Lb with H2O2, elemental sulfur or elemental selenium led to the corresponding oxidized products 4a/b-6a/b. Both La and Lb behave as didentate ligands towards late transition metals. Reaction of La or Lb with [MX2(cod)] (M = Pd, Pt; X = Cl, Me) gave chelate complexes 7a/b-10a/b. Reaction of La or Lb with [AuCl(tht)] or [{RuCl(mu-Cl)(p-MeC(6)H(4)iPr)}(2)] gave the didentate bridging complexes 11a/b and 12a. All compounds have been fully characterised by microanalysis, IR, H-1 and P-31(H-1) NMR spectroscopy, and EI/CI/FAB mass spectrometry. (1)Hi{P-31} NMR and H-1-C-13 correlation experiments were used to confirm the spectral assignments where necessary. Two compounds were structurally characterised by X-ray crystallographic analysis. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).