Symetries and asymetries of the immune system response: a categorification approach

Jean François Mascari; Damien Giacchero; Nikolaos Sfakianakis

doi:10.1109/BIBM.2017.8217876

Symetries and asymetries of the immune system response: a categorification approach

Jean François Mascari, Damien Giacchero, Nikolaos Sfakianakis

Applied Mathematics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A new modeling approach and conceptual framework to the immune system response and its dual role with respect to cancer is proposed based on Applied Category Theory. States of cells and pathogenes are structured as mathematical structures (categories), the interactions, at a given phase, between cells of the immune system and pathogenes, correspond to a pair of adjunctions (adjoint functors), the interaction process consisting of the sequential composition of an identification phase, a preparation phase and an activation phase is modeled by the composition of maps of adjunctions: the approach is illustrated by considering the Cancer-Immunity Cycle. A third dimension is needed to model Cancer Immunoediting. The categorical foundations of our approach is based on Marco Grandis and Rober Paré theory of Intercategories.

Original language	English
Title of host publication	Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
Editors	Xiaohua Tony Hu, Chi-Ren Shyu, Yana Bromberg, Jean Gao, Yang Gong, Dmitry Korkin, Illhoi Yoo, Jane Huiru Zheng
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1451-1454
Number of pages	4
Volume	2017-January
ISBN (Electronic)	9781509030491, 9781509030507
DOIs	https://doi.org/10.1109/BIBM.2017.8217876
Publication status	Published - 15 Dec 2017
Event	2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017 - Kansas City, United States Duration: 13 Nov 2017 → 16 Nov 2017 https://muii.missouri.edu/bibm2017/

Conference

Conference	2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
Abbreviated title	BIBM 2017
Country/Territory	United States
City	Kansas City
Period	13/11/17 → 16/11/17
Internet address	https://muii.missouri.edu/bibm2017/

Keywords

Cancer
Cancer immunoediting
Cancerimmunity cycle
Category theory
Immune system

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/BIBM.2017.8217876

Cite this

Mascari, J. F., Giacchero, D., & Sfakianakis, N. (2017). Symetries and asymetries of the immune system response: a categorification approach. In X. T. Hu, C.-R. Shyu, Y. Bromberg, J. Gao, Y. Gong, D. Korkin, I. Yoo, & J. H. Zheng (Eds.), Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017 (Vol. 2017-January, pp. 1451-1454). Article 8217876 Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM.2017.8217876

Mascari, Jean François ; Giacchero, Damien ; Sfakianakis, Nikolaos. / Symetries and asymetries of the immune system response : a categorification approach. Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017. editor / Xiaohua Tony Hu ; Chi-Ren Shyu ; Yana Bromberg ; Jean Gao ; Yang Gong ; Dmitry Korkin ; Illhoi Yoo ; Jane Huiru Zheng. Vol. 2017-January Institute of Electrical and Electronics Engineers Inc., 2017. pp. 1451-1454

@inproceedings{2f931483a0ea47a5b5c705a11e81e2be,

title = "Symetries and asymetries of the immune system response: a categorification approach",

abstract = "A new modeling approach and conceptual framework to the immune system response and its dual role with respect to cancer is proposed based on Applied Category Theory. States of cells and pathogenes are structured as mathematical structures (categories), the interactions, at a given phase, between cells of the immune system and pathogenes, correspond to a pair of adjunctions (adjoint functors), the interaction process consisting of the sequential composition of an identification phase, a preparation phase and an activation phase is modeled by the composition of maps of adjunctions: the approach is illustrated by considering the Cancer-Immunity Cycle. A third dimension is needed to model Cancer Immunoediting. The categorical foundations of our approach is based on Marco Grandis and Rober Par{\'e} theory of Intercategories.",

keywords = "Cancer, Cancer immunoediting, Cancerimmunity cycle, Category theory, Immune system",

author = "Mascari, {Jean Fran{\c c}ois} and Damien Giacchero and Nikolaos Sfakianakis",

year = "2017",

month = dec,

day = "15",

doi = "10.1109/BIBM.2017.8217876",

language = "English",

volume = "2017-January",

pages = "1451--1454",

editor = "Hu, {Xiaohua Tony} and Chi-Ren Shyu and Yana Bromberg and Jean Gao and Yang Gong and Dmitry Korkin and Illhoi Yoo and Zheng, {Jane Huiru}",

booktitle = "Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

address = "United States",

note = "2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017, BIBM 2017 ; Conference date: 13-11-2017 Through 16-11-2017",

url = "https://muii.missouri.edu/bibm2017/",

}

Mascari, JF, Giacchero, D & Sfakianakis, N 2017, Symetries and asymetries of the immune system response: a categorification approach. in XT Hu, C-R Shyu, Y Bromberg, J Gao, Y Gong, D Korkin, I Yoo & JH Zheng (eds), Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017. vol. 2017-January, 8217876, Institute of Electrical and Electronics Engineers Inc., pp. 1451-1454, 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017, Kansas City, Missouri, United States, 13/11/17. https://doi.org/10.1109/BIBM.2017.8217876

Symetries and asymetries of the immune system response: a categorification approach. / Mascari, Jean François; Giacchero, Damien; Sfakianakis, Nikolaos.
Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017. ed. / Xiaohua Tony Hu; Chi-Ren Shyu; Yana Bromberg; Jean Gao; Yang Gong; Dmitry Korkin; Illhoi Yoo; Jane Huiru Zheng. Vol. 2017-January Institute of Electrical and Electronics Engineers Inc., 2017. p. 1451-1454 8217876.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Symetries and asymetries of the immune system response

T2 - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017

AU - Mascari, Jean François

AU - Giacchero, Damien

AU - Sfakianakis, Nikolaos

PY - 2017/12/15

Y1 - 2017/12/15

N2 - A new modeling approach and conceptual framework to the immune system response and its dual role with respect to cancer is proposed based on Applied Category Theory. States of cells and pathogenes are structured as mathematical structures (categories), the interactions, at a given phase, between cells of the immune system and pathogenes, correspond to a pair of adjunctions (adjoint functors), the interaction process consisting of the sequential composition of an identification phase, a preparation phase and an activation phase is modeled by the composition of maps of adjunctions: the approach is illustrated by considering the Cancer-Immunity Cycle. A third dimension is needed to model Cancer Immunoediting. The categorical foundations of our approach is based on Marco Grandis and Rober Paré theory of Intercategories.

AB - A new modeling approach and conceptual framework to the immune system response and its dual role with respect to cancer is proposed based on Applied Category Theory. States of cells and pathogenes are structured as mathematical structures (categories), the interactions, at a given phase, between cells of the immune system and pathogenes, correspond to a pair of adjunctions (adjoint functors), the interaction process consisting of the sequential composition of an identification phase, a preparation phase and an activation phase is modeled by the composition of maps of adjunctions: the approach is illustrated by considering the Cancer-Immunity Cycle. A third dimension is needed to model Cancer Immunoediting. The categorical foundations of our approach is based on Marco Grandis and Rober Paré theory of Intercategories.

KW - Cancer

KW - Cancer immunoediting

KW - Cancerimmunity cycle

KW - Category theory

KW - Immune system

U2 - 10.1109/BIBM.2017.8217876

DO - 10.1109/BIBM.2017.8217876

M3 - Conference contribution

AN - SCOPUS:85046024186

VL - 2017-January

SP - 1451

EP - 1454

BT - Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017

A2 - Hu, Xiaohua Tony

A2 - Shyu, Chi-Ren

A2 - Bromberg, Yana

A2 - Gao, Jean

A2 - Gong, Yang

A2 - Korkin, Dmitry

A2 - Yoo, Illhoi

A2 - Zheng, Jane Huiru

PB - Institute of Electrical and Electronics Engineers Inc.

Y2 - 13 November 2017 through 16 November 2017

ER -

Mascari JF, Giacchero D, Sfakianakis N. Symetries and asymetries of the immune system response: a categorification approach. In Hu XT, Shyu CR, Bromberg Y, Gao J, Gong Y, Korkin D, Yoo I, Zheng JH, editors, Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017. Vol. 2017-January. Institute of Electrical and Electronics Engineers Inc. 2017. p. 1451-1454. 8217876 doi: 10.1109/BIBM.2017.8217876

Symetries and asymetries of the immune system response: a categorification approach

Abstract

Conference

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this