Susceptibility of pseudomonas pseudomallei to new β-lactam and aminoglycoside antibiotics

David W. Mceniry, Stephen H. Gillespie*, David Felmingham

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Pseudomonas pseudomallei is resistant to many antimicrobial agents. We determined the susceptibility to twelve β-lactams and six aminoglycosides of twelve isolates of P. pseudomallei. Imipenem (MIC range 0·5-1·0 mg/l; MIC90 10 mg/l), ceftazidime (MIC range 1-8 mg/l; MIC90 8·0 mg/l), amoxycillin/clavulanate (MIC range 4-8 mg/l; MIC90 8·0 mg/l), piperacillin (MIC range 4-16 mg/l; MIC90 8·0 mg/l), and carumonam (MIC range 4-;16 mg/l; MIC90 8·0 mg/l) were the most active. Aminoglycosides were relatively inactive, for example, gentamicin (MIC range 16-64 mg/l; MIC90 64 mg/l), netilmicin (MIC range 16-128 mg/l; MIC90 128 mg/l) and amikacin (MIC range 32-64 mg/l; MIC90 64 mg/l).

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 1988

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