Suprasensitivity to calcitonin gene-related peptide but not vasoactive intestinal peptide in women with chronic pelvic pain

R W Stones, D C Thomas, R W Beard

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Chronic pelvic pain in women is associated with radiological evidence of pelvic venous dilatation and reduced flow, termed 'pelvic congestion'. The aim of this study was to elucidate a possible role in this condition for vasoactive intestinal peptide and calcitonin gene-related peptide, both localized in perivascular nerves in the ovaries and uterus. Healthy volunteers and women with chronic pelvic pain and venous congestion received intravenous infusions of vasoactive intestinal peptide (n = 15), calcitonin gene-related peptide (n = 15) or a bland infusate (n = 7). Changes in the uterovaginal and skin blood flow were assessed by continuous measurement of vaginal, axillary, cheek and hand temperature. During calcitonin gene-related peptide infusion median hand temperature changes were +0.97 degrees C in women with pelvic pain and -0.03 degrees C in healthy volunteers (p
Original languageEnglish
Pages (from-to)343-8
Number of pages6
JournalClinical autonomic research : official journal of the Clinical Autonomic Research Society
Volume2
Issue number5
Publication statusPublished - Oct 1992

Keywords

  • Adult
  • Blood Pressure
  • Body Temperature
  • Calcitonin Gene-Related Peptide
  • Chronic Disease
  • Female
  • Humans
  • Infusions, Intravenous
  • Pain
  • Pain Measurement
  • Pelvis
  • Vasoactive Intestinal Peptide

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