Supramolecular structures of N-4-substituted 2,4-diamino-6-benzyloxy-5-nitrosopyrimidines

M Melguizo, A Quesada, J N Low, C Glidewell

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

The molecular and supramolecular structures of eight N-4-substituted 2,4-diamino-6-benzyloxy-5-nitrosopyrimidines are discussed, along with one analogue containing no nitroso substituent. The nitroso derivatives all exhibit polarized molecular-electronic structures leading to extensive charge-assisted hydrogen bonding between the molecules. The intermolecular interactions include hard hydrogen bonds of N-H...O and N-H...N types, together with O-H...O and O-H...N types in the monohydrate of 2-amino-6-benzyloxy-4- piperidino-5-nitrosopyrimidine, soft hydrogen bonds of C-H...O, C-H...pi(arene) and N-H...pi(arene) types and aromatic pi...pi stacking interactions. The predominant supramolecular structure types take the form of chains and sheets, but no two of the structures determined here exhibit the same combination of hydrogen-bond types.

Original languageEnglish
Pages (from-to)263-276
Number of pages14
JournalActa Crystallographica. Section B, Structural Science
Volume59
DOIs
Publication statusPublished - Apr 2003

Keywords

  • CRYSTAL-STRUCTURE PREDICTION
  • SMALL ORGANIC-MOLECULES
  • DIFFRACTION DATA
  • RING
  • REFINEMENT
  • INTERPLAY

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