SUMO and transcriptional regulation

D Girdwood; MH Tatham; Ronald Thomas Hay

doi:10.1016/j.semcdb.2003.12.001

SUMO and transcriptional regulation

D Girdwood, MH Tatham, Ronald Thomas Hay

School of Biology

Research output: Contribution to journal › Article › peer-review

Abstract

The small ubiquitin-like modifier (SUMO) is covalently attached to lysine residues in target proteins and in doing so changes the properties of the modified protein. Here we examine the role of SUMO modification in transcriptional regulation. SUMO addition to components of the transcriptional apparatus does not have a common consequence as it can both activate and repress transcription. In most cases, however, SUMO modification of transcription factors leads to repression and various models to explain this, ranging from retention in nuclear bodies to recruitment of histone deacetylases are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	201-210
Number of pages	10
Journal	Seminars in Cell and Developmental Biology
Volume	15
Issue number	2
DOIs	https://doi.org/10.1016/j.semcdb.2003.12.001
Publication status	Published - Apr 2004

Keywords

SUMO
E3 ligase
transcriptional repression
Ubc9
sub-nuclear targeting
ubiquitin-like protein
PML body
UBIQUITIN-LIKE PROTEIN
ACUTE PROMYELOCYTIC LEUKEMIA
NUCLEAR-PORE COMPLEX
RECEPTOR-DEPENDENT TRANSCRIPTION
CONJUGATING ENZYME UBC9
AXIN-BINDING PROTEIN
COVALENT MODIFICATION
ANDROGEN RECEPTOR
BETA-CATENIN
E3 LIGASE

Access to Document

10.1016/j.semcdb.2003.12.001

Cite this

@article{a9f87b96766a48a49cf7a33da5be730d,

title = "SUMO and transcriptional regulation",

abstract = "The small ubiquitin-like modifier (SUMO) is covalently attached to lysine residues in target proteins and in doing so changes the properties of the modified protein. Here we examine the role of SUMO modification in transcriptional regulation. SUMO addition to components of the transcriptional apparatus does not have a common consequence as it can both activate and repress transcription. In most cases, however, SUMO modification of transcription factors leads to repression and various models to explain this, ranging from retention in nuclear bodies to recruitment of histone deacetylases are discussed. (C) 2003 Elsevier Ltd. All rights reserved.",

keywords = "SUMO, E3 ligase, transcriptional repression, Ubc9, sub-nuclear targeting, ubiquitin-like protein, PML body, UBIQUITIN-LIKE PROTEIN, ACUTE PROMYELOCYTIC LEUKEMIA, NUCLEAR-PORE COMPLEX, RECEPTOR-DEPENDENT TRANSCRIPTION, CONJUGATING ENZYME UBC9, AXIN-BINDING PROTEIN, COVALENT MODIFICATION, ANDROGEN RECEPTOR, BETA-CATENIN, E3 LIGASE",

author = "D Girdwood and MH Tatham and Hay, {Ronald Thomas}",

year = "2004",

month = apr,

doi = "10.1016/j.semcdb.2003.12.001",

language = "English",

volume = "15",

pages = "201--210",

journal = "Seminars in Cell and Developmental Biology",

issn = "1084-9521",

publisher = "Academic Press/Elsevier ",

number = "2",

}

TY - JOUR

T1 - SUMO and transcriptional regulation

AU - Girdwood, D

AU - Tatham, MH

AU - Hay, Ronald Thomas

PY - 2004/4

Y1 - 2004/4

N2 - The small ubiquitin-like modifier (SUMO) is covalently attached to lysine residues in target proteins and in doing so changes the properties of the modified protein. Here we examine the role of SUMO modification in transcriptional regulation. SUMO addition to components of the transcriptional apparatus does not have a common consequence as it can both activate and repress transcription. In most cases, however, SUMO modification of transcription factors leads to repression and various models to explain this, ranging from retention in nuclear bodies to recruitment of histone deacetylases are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

AB - The small ubiquitin-like modifier (SUMO) is covalently attached to lysine residues in target proteins and in doing so changes the properties of the modified protein. Here we examine the role of SUMO modification in transcriptional regulation. SUMO addition to components of the transcriptional apparatus does not have a common consequence as it can both activate and repress transcription. In most cases, however, SUMO modification of transcription factors leads to repression and various models to explain this, ranging from retention in nuclear bodies to recruitment of histone deacetylases are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

KW - SUMO

KW - E3 ligase

KW - transcriptional repression

KW - Ubc9

KW - sub-nuclear targeting

KW - ubiquitin-like protein

KW - PML body

KW - UBIQUITIN-LIKE PROTEIN

KW - ACUTE PROMYELOCYTIC LEUKEMIA

KW - NUCLEAR-PORE COMPLEX

KW - RECEPTOR-DEPENDENT TRANSCRIPTION

KW - CONJUGATING ENZYME UBC9

KW - AXIN-BINDING PROTEIN

KW - COVALENT MODIFICATION

KW - ANDROGEN RECEPTOR

KW - BETA-CATENIN

KW - E3 LIGASE

U2 - 10.1016/j.semcdb.2003.12.001

DO - 10.1016/j.semcdb.2003.12.001

M3 - Article

SN - 1084-9521

VL - 15

SP - 201

EP - 210

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

IS - 2

ER -

SUMO and transcriptional regulation

Abstract

Keywords

Access to Document

Fingerprint

Cite this