SUMO and transcriptional regulation

D Girdwood, MH Tatham, Ronald Thomas Hay

Research output: Contribution to journalArticlepeer-review

153 Citations (Scopus)

Abstract

The small ubiquitin-like modifier (SUMO) is covalently attached to lysine residues in target proteins and in doing so changes the properties of the modified protein. Here we examine the role of SUMO modification in transcriptional regulation. SUMO addition to components of the transcriptional apparatus does not have a common consequence as it can both activate and repress transcription. In most cases, however, SUMO modification of transcription factors leads to repression and various models to explain this, ranging from retention in nuclear bodies to recruitment of histone deacetylases are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)201-210
Number of pages10
JournalSeminars in Cell and Developmental Biology
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 2004

Keywords

  • SUMO
  • E3 ligase
  • transcriptional repression
  • Ubc9
  • sub-nuclear targeting
  • ubiquitin-like protein
  • PML body
  • UBIQUITIN-LIKE PROTEIN
  • ACUTE PROMYELOCYTIC LEUKEMIA
  • NUCLEAR-PORE COMPLEX
  • RECEPTOR-DEPENDENT TRANSCRIPTION
  • CONJUGATING ENZYME UBC9
  • AXIN-BINDING PROTEIN
  • COVALENT MODIFICATION
  • ANDROGEN RECEPTOR
  • BETA-CATENIN
  • E3 LIGASE

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