SUMO: A history of modification

R T Hay

Research output: Contribution to journalReview articlepeer-review

1243 Citations (Scopus)

Abstract

The small ubiquitin-like modifier (SUMO) is covalently linked to a variety of proteins and is deconjugated by SUMO-specific proteases. A characteristic of SUMO modification is that the biological consequences of conjugation do not appear proportionate to the small fraction of substrate that is modified. SUMO conjugation appears to alter the long-term fate of the modified protein even though the SUMO may be rapidly deconjugated. Thus an unmodified protein with a history of SUMO modification may have different properties from a protein that never has been modified. Here, the diverse effects of SUMO modification are discussed and models proposed to explain SUMO actions.

Original languageEnglish
Pages (from-to)112
Number of pages12
JournalMolecular Cell
Volume18
Publication statusPublished - 1 Apr 2005

Keywords

  • NUCLEAR-PORE COMPLEX
  • UBIQUITIN-CONJUGATING ENZYME
  • MEDIATED TRANSCRIPTIONAL REPRESSION
  • KAPPA-B ACTIVATION
  • ANDROGEN RECEPTOR
  • PROTEIN SUMO-1
  • E3 LIGASE
  • SACCHAROMYCES-CEREVISIAE
  • SUBSTRATE RECOGNITION
  • COVALENT MODIFICATION

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