Substrate specificity in enzymatic fluorination.  The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates

The fluorinase enzyme from Streptomyces cattleya displays an unusual ability in biocatalysis in that it forms a C - F bond. We now report that the enzyme will accept 2'-deoxyadenosine in place of adenosine substrates, and structural evidence reveals a reorganisation in hydrogen bonding to accommodate this substrate series. It emerges from this study that the enzyme does not require a planar ribose conformation of the substrate to catalyse C - F bond formation.