Subcellular localization and interactions among TGB proteins of cowpea mild mottle virus

S L Carvalho, J Tilsner, A R Figueira, C M Carvalho*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Cowpea mild mottle virus (CPMMV) is a flexuous filamentous virus that belongs to the genus Carlavirus (family Betaflexiviridae). The CPMMV genome contains six open reading frames (ORFs), among which the triple gene block (TGB), encoded by ORFs 2 to 4, has been reported to encode movement proteins for different viruses. The subcellular localization of the TGB proteins of CPMMV isolate CPMMV:BR:MG:09:2 was analysed by transient expression of each protein fused to a fluorophore. Overall, the accumulation pattern and interactions among CPMMV TGB proteins (TGBp) were similar to those of their counterparts from the potex-like group. Considering these similarities, we evaluated the potential interactions between the TGB proteins of CPMMV and of potato virus X, which could complement cell-to-cell movement. The TGBp2 and TGBp3 of PVX had an effect on CPMMV TGBp1, directing it to the plasmodesmata, but the reverse was not true.

Original languageEnglish
Pages (from-to)2555-2566
Number of pages12
JournalArchives of Virology
Early online date21 Oct 2022
Publication statusPublished - 1 Dec 2022


  • Cowpea mild mottle virus
  • Triple gene block
  • Subcellular localization


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