Studies towards the synthesis of neopeltolide: synthesis of a ring closing metathesis macrocyclization precursor

Gordon John Florence, Romain Cadou

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

An advanced ring-closing metathesis precursor for the synthesis of the marine macrolide neopeltolide is prepared in a stereocontrolled manner by the coupling of the C2–C10 and C11–C16 subunits. The metathesis reaction of 4 with Grubbs’ II or Nolan’s indenylidene catalyst led to the unexpected formation of cycloheptene 18.
Original languageEnglish
Pages (from-to)5761-5763
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number44
Early online date7 Sept 2010
DOIs
Publication statusPublished - 3 Nov 2010

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