Studies towards the synthesis of neopeltolide: synthesis of a ring closing metathesis macrocyclization precursor

Gordon John Florence; Romain Cadou

doi:10.1016/j.tetlet.2010.08.118

Studies towards the synthesis of neopeltolide: synthesis of a ring closing metathesis macrocyclization precursor

Research output: Contribution to journal › Article › peer-review

Abstract

An advanced ring-closing metathesis precursor for the synthesis of the marine macrolide neopeltolide is prepared in a stereocontrolled manner by the coupling of the C2–C10 and C11–C16 subunits. The metathesis reaction of 4 with Grubbs’ II or Nolan’s indenylidene catalyst led to the unexpected formation of cycloheptene 18.

Original language	English
Pages (from-to)	5761-5763
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	44
Early online date	7 Sept 2010
DOIs	https://doi.org/10.1016/j.tetlet.2010.08.118
Publication status	Published - 3 Nov 2010

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10.1016/j.tetlet.2010.08.118

RS Uni Research Fellowship Renewal 2010: University Research Fellowship - New Methods and Strategies for the Synthesis of Bioactive Natural Products
Florence, G. J. (PI)
1/10/10 → 30/09/13
Project: Fellowship

Cite this

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title = "Studies towards the synthesis of neopeltolide: synthesis of a ring closing metathesis macrocyclization precursor",

abstract = "An advanced ring-closing metathesis precursor for the synthesis of the marine macrolide neopeltolide is prepared in a stereocontrolled manner by the coupling of the C2–C10 and C11–C16 subunits. The metathesis reaction of 4 with Grubbs{\textquoteright} II or Nolan{\textquoteright}s indenylidene catalyst led to the unexpected formation of cycloheptene 18.",

author = "Florence, {Gordon John} and Romain Cadou",

year = "2010",

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day = "3",

doi = "10.1016/j.tetlet.2010.08.118",

language = "English",

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journal = "Tetrahedron Letters",

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T1 - Studies towards the synthesis of neopeltolide

T2 - synthesis of a ring closing metathesis macrocyclization precursor

AU - Florence, Gordon John

AU - Cadou, Romain

PY - 2010/11/3

Y1 - 2010/11/3

N2 - An advanced ring-closing metathesis precursor for the synthesis of the marine macrolide neopeltolide is prepared in a stereocontrolled manner by the coupling of the C2–C10 and C11–C16 subunits. The metathesis reaction of 4 with Grubbs’ II or Nolan’s indenylidene catalyst led to the unexpected formation of cycloheptene 18.

AB - An advanced ring-closing metathesis precursor for the synthesis of the marine macrolide neopeltolide is prepared in a stereocontrolled manner by the coupling of the C2–C10 and C11–C16 subunits. The metathesis reaction of 4 with Grubbs’ II or Nolan’s indenylidene catalyst led to the unexpected formation of cycloheptene 18.

U2 - 10.1016/j.tetlet.2010.08.118

DO - 10.1016/j.tetlet.2010.08.118

M3 - Article

SN - 0040-4039

VL - 51

SP - 5761

EP - 5763

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 44

ER -

Studies towards the synthesis of neopeltolide: synthesis of a ring closing metathesis macrocyclization precursor

Abstract

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Projects

RS Uni Research Fellowship Renewal 2010: University Research Fellowship - New Methods and Strategies for the Synthesis of Bioactive Natural Products

Cite this