Abstract
Electrospray mass spectrometry was used to investigate the mode of inhibition of porcine pancreatic elastase by
chloromethyl ketones and other inhibitors, such as 3,4-dichloroisocoumarin. The results provided confirmation and
clarification of proposed mechanisms of inhibition, providing evidence consistent with the formation of several
intermediates, including a hemiketal species.
chloromethyl ketones and other inhibitors, such as 3,4-dichloroisocoumarin. The results provided confirmation and
clarification of proposed mechanisms of inhibition, providing evidence consistent with the formation of several
intermediates, including a hemiketal species.
| Original language | English |
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| Journal | Journal of the Chemical Society, Chemical Communications |
| DOIs | |
| Publication status | Published - 1992 |