Studies on the inhibition of porcine pancreatic elastase using electrospray mass spectrometry

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Abstract

Electrospray mass spectrometry was used to investigate the mode of inhibition of porcine pancreatic elastase by
chloromethyl ketones and other inhibitors, such as 3,4-dichloroisocoumarin. The results provided confirmation and
clarification of proposed mechanisms of inhibition, providing evidence consistent with the formation of several
intermediates, including a hemiketal species.
Original languageEnglish
JournalJournal of the Chemical Society, Chemical Communications
DOIs
Publication statusPublished - 1992

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