Structural basis for cyclophellitol inhibition of a beta-glucosidase

Tracey M. Gloster, Robert Madsen, Gideon J. Davies

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

The structural basis for beta-glucosidase inhibition by cyclophellitol is demonstrated using X-ray crystallography, enzyme kinetics and mass spectrometry.

Original languageEnglish
Pages (from-to)444-446
Number of pages3
JournalOrganic & Biomolecular Chemistry
Volume5
Issue number3
DOIs
Publication statusPublished - 2007

Keywords

  • ENZYME INTERMEDIATE
  • MECHANISM
  • (+)-CYCLOPHELLITOL
  • IDENTIFICATION
  • GLYCOSIDASES
  • NUCLEOPHILE
  • SNAPSHOTS

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