Structural basis for cyclophellitol inhibition of a beta-glucosidase

Tracey M. Gloster; Robert Madsen; Gideon J. Davies

doi:10.1039/b616590g

Structural basis for cyclophellitol inhibition of a beta-glucosidase

Tracey M. Gloster, Robert Madsen, Gideon J. Davies

Research output: Contribution to journal › Article › peer-review

Abstract

The structural basis for beta-glucosidase inhibition by cyclophellitol is demonstrated using X-ray crystallography, enzyme kinetics and mass spectrometry.

Original language	English
Pages (from-to)	444-446
Number of pages	3
Journal	Organic & Biomolecular Chemistry
Volume	5
Issue number	3
DOIs	https://doi.org/10.1039/b616590g
Publication status	Published - 2007

Keywords

ENZYME INTERMEDIATE
MECHANISM
(+)-CYCLOPHELLITOL
IDENTIFICATION
GLYCOSIDASES
NUCLEOPHILE
SNAPSHOTS

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10.1039/b616590g

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@article{dbf2225cf0004bd2a61c0f2a0fea7304,

title = "Structural basis for cyclophellitol inhibition of a beta-glucosidase",

abstract = "The structural basis for beta-glucosidase inhibition by cyclophellitol is demonstrated using X-ray crystallography, enzyme kinetics and mass spectrometry.",

keywords = "ENZYME INTERMEDIATE, MECHANISM, (+)-CYCLOPHELLITOL, IDENTIFICATION, GLYCOSIDASES, NUCLEOPHILE, SNAPSHOTS",

author = "Gloster, {Tracey M.} and Robert Madsen and Davies, {Gideon J.}",

year = "2007",

doi = "10.1039/b616590g",

language = "English",

volume = "5",

pages = "444--446",

journal = "Organic & Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "3",

}

TY - JOUR

T1 - Structural basis for cyclophellitol inhibition of a beta-glucosidase

AU - Gloster, Tracey M.

AU - Madsen, Robert

AU - Davies, Gideon J.

PY - 2007

Y1 - 2007

N2 - The structural basis for beta-glucosidase inhibition by cyclophellitol is demonstrated using X-ray crystallography, enzyme kinetics and mass spectrometry.

AB - The structural basis for beta-glucosidase inhibition by cyclophellitol is demonstrated using X-ray crystallography, enzyme kinetics and mass spectrometry.

KW - ENZYME INTERMEDIATE

KW - MECHANISM

KW - (+)-CYCLOPHELLITOL

KW - IDENTIFICATION

KW - GLYCOSIDASES

KW - NUCLEOPHILE

KW - SNAPSHOTS

U2 - 10.1039/b616590g

DO - 10.1039/b616590g

M3 - Article

SN - 1477-0520

VL - 5

SP - 444

EP - 446

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

IS - 3

ER -

Structural basis for cyclophellitol inhibition of a beta-glucosidase

Abstract

Keywords

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