First microwave accelerated Hiyama couplings: clean cross-coupling of aryl chlorides within minutes.

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Abstract

The first microwave-accelerated Hiyama cross-coupling reactions are reported. The reactions of aryl bromides and activated aryl chlorides with PhSi(OMe)(3) [or C2H3Si(OMe)(3)] are complete within minutes using a modified catalyst system that can be prepared from commercially available reagents in situ. The microwave-accelerated reactions proceed under relatively mild conditions (110-115degreesC).

Original languageEnglish
Pages (from-to)303
Number of pages303
JournalAdvanced Synthesis & Catalysis
Volume347
DOIs
Publication statusPublished - Feb 2005

Keywords

  • cross-coupling
  • homogeneous catalysis
  • microwave heating
  • palladium
  • phosphane ligands
  • ORGANIC HALIDES
  • REAGENTS
  • CATALYST
  • BROMIDES
  • PHOSPHINES
  • COMPLEXES
  • AMINATION
  • NEGISHI
  • SYSTEM

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