Strategies for synthesis of yardsticks and abaci for nanometre distance measurements by pulsed EPR

Silvia Valera, Bela Ernest Bode

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Pulsed electron paramagnetic resonance (EPR) techniques have been found to be an efficient tool for elucidation of structure in complex biological systems as they give access to distances in the nanometre range. These measurements can provide additional structural information such as relative orientations, structural flexibility or aggregation states. A wide variety of model systems for calibration and optimisation of pulsed experiments has been synthesised. Their design is based on mimicking biological systems or materials in specific properties such as the distances themselves and the distance distributions. Here, we review selected approaches to the synthesis of chemical systems bearing two or more spin centres, such as nitroxide or trityl radicals, metal ions or combinations thereof and sketch their application in pulsed EPR distance measurements.
Original languageEnglish
Pages (from-to)20227-20256
Number of pages30
JournalMolecules
Volume19
Issue number12
DOIs
Publication statusPublished - 3 Dec 2014

Keywords

  • Model systems
  • Synthesis
  • EPR distance measurements
  • Nitroxide and trityl radicals
  • Metal centres

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