Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling

CV Ramana, MP Gil, RD Schreiber, GR Stark*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

483 Citations (Scopus)

Abstract

The paradigm that emerged from studies during the past decade established a central role for Jak-Stat (signal transducer and activator of transcription) signaling pathways in promoting the diverse cellular responses induced by interferon gamma(IFN-gamma). However, recent studies have shown that the IFN-gamma receptor activates additional signaling pathways and can regulate gene expression by Stat1-independent pathways. The diversity of gene-expression patterns mediated by Stat1-dependent and -independent mechanisms and the balance between these two pathways play an important role in the biological response to IFN-gamma.

Original languageEnglish
Pages (from-to)96-101
Number of pages6
JournalTrends in Immunology
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 2002

Keywords

  • INTERFERON-GAMMA
  • TARGETED DISRUPTION
  • GENE-EXPRESSION
  • TRANSCRIPTIONAL ACTIVATION
  • TYROSINE PHOSPHORYLATION
  • SERINE PHOSPHORYLATION
  • JANUS KINASES
  • CELL-SURVIVAL
  • STAT1
  • RECEPTOR

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