Staphylococcus aureus: superbug, super genome?

JA Lindsay, MTG Holden*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

286 Citations (Scopus)

Abstract

Staphylococcus aureus is a common cause of infection in both hospitals and the community, and it is becoming increasingly virulent and resistant to antibiotics. The recent sequencing of seven strains of S. aureus provides unprecedented information about its genome diversity. Subtle differences in core (stable) regions of the genome have been exploited by multi-locus sequence typing (MLST) to understand S. aureus population structure. Dramatic differences in the carriage and spread of accessory genes, including those involved in virulence and resistance, contribute to the emergence of new strains with healthcare implications. Understanding the differences between S. aureus genomes and the controls that govern these changes is helping to improve our knowledge of S. aureus pathogenicity and to predict the evolution of super-superbugs.

Original languageEnglish
Pages (from-to)378-385
Number of pages8
JournalTrends in Microbiology
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 2004

Keywords

  • PANTON-VALENTINE LEUKOCIDIN
  • CASSETTE CHROMOSOME MEC
  • COMPLETE NUCLEOTIDE-SEQUENCE
  • PATHOGENICITY ISLANDS
  • ANTIMICROBIAL RESISTANCE
  • MOLECULAR ANALYSIS
  • PHAGE CONVERSION
  • GENETIC ELEMENT
  • VIRULENCE GENES
  • SEX-PHEROMONE

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