Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition

Nadège Minois, Patrick Rockenfeller, Terry K Smith, Didac Carmona-Gutierrez

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)
2 Downloads (Pure)

Abstract

Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating that it is also able to improve locomotor performance in aged flies. Spermidine's mechanism of action on aging has been primarily related to general protein hypoacetylation that subsequently induces autophagy. Here, we suggest that the molecular targets of spermidine also include lipid metabolism: Spermidine-fed flies contain more triglycerides and show altered fatty acid and phospholipid profiles. We further determine that most of these metabolic changes are regulated through autophagy. Collectively, our data suggests an additional and novel lipid-mediated mechanism of action for spermidine-induced autophagy.
Original languageEnglish
Article numbere102435
Number of pages11
JournalPLoS One
Volume9
Issue number7
DOIs
Publication statusPublished - 10 Jul 2014

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