Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition

Nadège Minois; Patrick Rockenfeller; Terry K Smith; Didac Carmona-Gutierrez

doi:10.1371/journal.pone.0102435

Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition

Nadège Minois, Patrick Rockenfeller, Terry K Smith, Didac Carmona-Gutierrez

Research output: Contribution to journal › Article › peer-review

Abstract

Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating that it is also able to improve locomotor performance in aged flies. Spermidine's mechanism of action on aging has been primarily related to general protein hypoacetylation that subsequently induces autophagy. Here, we suggest that the molecular targets of spermidine also include lipid metabolism: Spermidine-fed flies contain more triglycerides and show altered fatty acid and phospholipid profiles. We further determine that most of these metabolic changes are regulated through autophagy. Collectively, our data suggests an additional and novel lipid-mediated mechanism of action for spermidine-induced autophagy.

Original language	English
Article number	e102435
Number of pages	11
Journal	PLoS One
Volume	9
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0102435
Publication status	Published - 10 Jul 2014

Access to Document

10.1371/journal.pone.0102435

minois2014ponee0102435
Copyright 2014 Minois et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Final published version, 774 KB

Cite this

@article{5b8d1d52620e4ddda7a9aa13fbed2879,

title = "Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition",

abstract = "Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating that it is also able to improve locomotor performance in aged flies. Spermidine's mechanism of action on aging has been primarily related to general protein hypoacetylation that subsequently induces autophagy. Here, we suggest that the molecular targets of spermidine also include lipid metabolism: Spermidine-fed flies contain more triglycerides and show altered fatty acid and phospholipid profiles. We further determine that most of these metabolic changes are regulated through autophagy. Collectively, our data suggests an additional and novel lipid-mediated mechanism of action for spermidine-induced autophagy.",

author = "Nad{\`e}ge Minois and Patrick Rockenfeller and Smith, {Terry K} and Didac Carmona-Gutierrez",

year = "2014",

month = jul,

day = "10",

doi = "10.1371/journal.pone.0102435",

language = "English",

volume = "9",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "7",

}

TY - JOUR

T1 - Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition

AU - Minois, Nadège

AU - Rockenfeller, Patrick

AU - Smith, Terry K

AU - Carmona-Gutierrez, Didac

PY - 2014/7/10

Y1 - 2014/7/10

N2 - Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating that it is also able to improve locomotor performance in aged flies. Spermidine's mechanism of action on aging has been primarily related to general protein hypoacetylation that subsequently induces autophagy. Here, we suggest that the molecular targets of spermidine also include lipid metabolism: Spermidine-fed flies contain more triglycerides and show altered fatty acid and phospholipid profiles. We further determine that most of these metabolic changes are regulated through autophagy. Collectively, our data suggests an additional and novel lipid-mediated mechanism of action for spermidine-induced autophagy.

AB - Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating that it is also able to improve locomotor performance in aged flies. Spermidine's mechanism of action on aging has been primarily related to general protein hypoacetylation that subsequently induces autophagy. Here, we suggest that the molecular targets of spermidine also include lipid metabolism: Spermidine-fed flies contain more triglycerides and show altered fatty acid and phospholipid profiles. We further determine that most of these metabolic changes are regulated through autophagy. Collectively, our data suggests an additional and novel lipid-mediated mechanism of action for spermidine-induced autophagy.

U2 - 10.1371/journal.pone.0102435

DO - 10.1371/journal.pone.0102435

M3 - Article

C2 - 25010732

SN - 1932-6203

VL - 9

JO - PLoS One

JF - PLoS One

IS - 7

M1 - e102435

ER -

Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition

Abstract

Access to Document

Fingerprint

Cite this