TY - JOUR
T1 - Speaking the host language
T2 - how Salmonella effector proteins manipulate the host
AU - Pillay, Timesh D.
AU - Hettiarachchi, Sahampath U.
AU - Gan, Jiyao
AU - Diaz-Del-Olmo, Ines
AU - Yu, Xiu Jun
AU - Muench, Janina H.
AU - Thurston, Teresa L.M.
AU - Pearson, Jaclyn S.
N1 - Funding: T.L.M.T. is supported by a Biotechnology and Biological Sciences Research Council (BBSRC) David Phillips Fellowship (BB/R011834/1) and a Medical Research Council (MRC) Research Grant MR/V031058/1, which also funds I.D.D.O. and J.M. This work was also supported by the Francis Crick Institute which receives its core funding from Cancer Research United Kingdom (CC 2075), the United Kingdom Medical Research Council (CC 2075), and the Wellcome Trust (CC 2075) to T.D.P. J.S.P. is supported by a Sylvia and Charles Viertel Senior Medical Research Fellowship (SMRF22008).
PY - 2023/6/6
Y1 - 2023/6/6
N2 - Salmonella injects over 40 virulence factors, termed effectors, into host cells to subvert diverse host cellular processes. Of these 40 Salmonella effectors, at least 25 have been described as mediating eukaryotic-like, biochemical post-translational modifications (PTMs) of host proteins, altering the outcome of infection. The downstream changes mediated by an effector’s enzymatic activity range from highly specific to multifunctional, and altogether their combined action impacts the function of an impressive array of host cellular processes, including signal transduction, membrane trafficking, and both innate and adaptive immune responses. Salmonella and related Gram-negative pathogens have been a rich resource for the discovery of unique enzymatic activities, expanding our understanding of host signalling networks, bacterial pathogenesis as well as basic biochemistry. In this review, we provide an up-to-date assessment of host manipulation mediated by the Salmonella type III secretion system injectosome, exploring the cellular effects of diverse effector activities with a particular focus on PTMs and the implications for infection outcomes. We also highlight activities and functions of numerous effectors that remain poorly characterized.
AB - Salmonella injects over 40 virulence factors, termed effectors, into host cells to subvert diverse host cellular processes. Of these 40 Salmonella effectors, at least 25 have been described as mediating eukaryotic-like, biochemical post-translational modifications (PTMs) of host proteins, altering the outcome of infection. The downstream changes mediated by an effector’s enzymatic activity range from highly specific to multifunctional, and altogether their combined action impacts the function of an impressive array of host cellular processes, including signal transduction, membrane trafficking, and both innate and adaptive immune responses. Salmonella and related Gram-negative pathogens have been a rich resource for the discovery of unique enzymatic activities, expanding our understanding of host signalling networks, bacterial pathogenesis as well as basic biochemistry. In this review, we provide an up-to-date assessment of host manipulation mediated by the Salmonella type III secretion system injectosome, exploring the cellular effects of diverse effector activities with a particular focus on PTMs and the implications for infection outcomes. We also highlight activities and functions of numerous effectors that remain poorly characterized.
KW - Biochemical mechanism
KW - Intracellular pathogen
KW - Post-translational modification
KW - Salmonella pathogenesis
KW - Type III effector protein
U2 - 10.1099/mic.0.001342
DO - 10.1099/mic.0.001342
M3 - Review article
C2 - 37279149
AN - SCOPUS:85161117369
SN - 1350-0872
VL - 169
JO - Microbiology
JF - Microbiology
IS - 6
M1 - 001342
ER -