Solid-phase synthesis and catalytic screening of polystyrene supported diphosphines

M. C. Samuels, F. J. L. Heutz, A. Grabulosa, P. C. J. Kamer

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

An efficient modular method towards the synthesis of a library of polystyrene supported diphosphine ligands by combining solid-phase synthesis with rational ligand design has been developed. These supported ligands, obtained in quantitative yield, were efficiently and effectively screened in Rh-catalysed asymmetric hydrogenation of several benchmark substrates.
Original languageEnglish
Pages (from-to)1793-1799
Number of pages7
JournalTopics in Catalysis
Volume59
Issue number19
Early online date25 Aug 2016
DOIs
Publication statusPublished - Dec 2016

Keywords

  • Solid-phase synthesis
  • Asymmetric catalysis
  • Combinatorial chemistry
  • P ligands
  • Catalyst immobilisation

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