Solid-phase parallel synthesis of phosphite ligands

Bert H. G. Swennenhuis; Ruifang Chen; Piet W. N. M. van Leeuwen; Johannes G. de Vries; Paul C. J. Kamer

doi:10.1021/ol703070x

Solid-phase parallel synthesis of phosphite ligands

Bert H. G. Swennenhuis, Ruifang Chen, Piet W. N. M. van Leeuwen, Johannes G. de Vries, Paul C. J. Kamer

Research output: Contribution to journal › Article › peer-review

Abstract

Various routes for the synthesis of polymer-bound phosphites and phosphoramidites have been investigated. In the presence of a suitable activator the supported phosphoramidites react cleanly with alcohols to give the corresponding monodentate phosphite ligands in solution. We have applied this novel solid-phase route in the parallel synthesis of several monodentate chiral and achiral phosphite ligands.

Original language	English
Pages (from-to)	989-992
Number of pages	4
Journal	Organic Letters
Volume	10
DOIs	https://doi.org/10.1021/ol703070x
Publication status	Published - 6 Mar 2008

Keywords

ALLYLIC ALKYLATION REACTIONS
RH-CATALYZED HYDROGENATION
MONODENTATE PHOSPHORAMIDITES
ASYMMETRIC HYDROGENATION
MONOPHOSPHITE LIGANDS
DERIVATIVES

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10.1021/ol703070x

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@article{f00050e1011640d893c76f681a86210d,

title = "Solid-phase parallel synthesis of phosphite ligands",

abstract = "Various routes for the synthesis of polymer-bound phosphites and phosphoramidites have been investigated. In the presence of a suitable activator the supported phosphoramidites react cleanly with alcohols to give the corresponding monodentate phosphite ligands in solution. We have applied this novel solid-phase route in the parallel synthesis of several monodentate chiral and achiral phosphite ligands.",

keywords = "ALLYLIC ALKYLATION REACTIONS, RH-CATALYZED HYDROGENATION, MONODENTATE PHOSPHORAMIDITES, ASYMMETRIC HYDROGENATION, MONOPHOSPHITE LIGANDS, DERIVATIVES",

author = "Swennenhuis, {Bert H. G.} and Ruifang Chen and {van Leeuwen}, {Piet W. N. M.} and {de Vries}, {Johannes G.} and Kamer, {Paul C. J.}",

year = "2008",

month = mar,

day = "6",

doi = "10.1021/ol703070x",

language = "English",

volume = "10",

pages = "989--992",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society (ACS)",

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TY - JOUR

T1 - Solid-phase parallel synthesis of phosphite ligands

AU - Swennenhuis, Bert H. G.

AU - Chen, Ruifang

AU - van Leeuwen, Piet W. N. M.

AU - de Vries, Johannes G.

AU - Kamer, Paul C. J.

PY - 2008/3/6

Y1 - 2008/3/6

N2 - Various routes for the synthesis of polymer-bound phosphites and phosphoramidites have been investigated. In the presence of a suitable activator the supported phosphoramidites react cleanly with alcohols to give the corresponding monodentate phosphite ligands in solution. We have applied this novel solid-phase route in the parallel synthesis of several monodentate chiral and achiral phosphite ligands.

AB - Various routes for the synthesis of polymer-bound phosphites and phosphoramidites have been investigated. In the presence of a suitable activator the supported phosphoramidites react cleanly with alcohols to give the corresponding monodentate phosphite ligands in solution. We have applied this novel solid-phase route in the parallel synthesis of several monodentate chiral and achiral phosphite ligands.

KW - ALLYLIC ALKYLATION REACTIONS

KW - RH-CATALYZED HYDROGENATION

KW - MONODENTATE PHOSPHORAMIDITES

KW - ASYMMETRIC HYDROGENATION

KW - MONOPHOSPHITE LIGANDS

KW - DERIVATIVES

UR - http://www.scopus.com/inward/record.url?scp=43549107348&partnerID=8YFLogxK

U2 - 10.1021/ol703070x

DO - 10.1021/ol703070x

M3 - Article

SN - 1523-7060

VL - 10

SP - 989

EP - 992

JO - Organic Letters

JF - Organic Letters

ER -

Solid-phase parallel synthesis of phosphite ligands

Abstract

Keywords

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