Snapshots: chromatin control of viral infection

David M Knipe, Paul M Lieberman, Jae U Jung, Alison A McBride, Kevin V Morris, Melanie Ott, David Margolis, Amelia Nieto, Michael Nevels, Robin J Parks, Thomas M Kristie

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)

Abstract

Like their cellular host counterparts, many invading viral pathogens must contend with, modulate, and utilize the host cell's chromatin machinery to promote efficient lytic infection or control persistent-latent states. While not intended to be comprehensive, this review represents a compilation of conceptual snapshots of the dynamic interplay of viruses with the chromatin environment. Contributions focus on chromatin dynamics during infection, viral circumvention of cellular chromatin repression, chromatin organization of large DNA viruses, tethering and persistence, viral interactions with cellular chromatin modulation machinery, and control of viral latency-reactivation cycles.
Original languageEnglish
Pages (from-to)141-56
Number of pages16
JournalVirology
Volume435
Issue number1
DOIs
Publication statusPublished - 5 Jan 2013

Keywords

  • Chromatin
  • Chromatin Assembly and Disassembly
  • DNA Viruses
  • Epigenesis, Genetic
  • Gene Expression Regulation, Viral
  • Genome, Viral
  • Host-Pathogen Interactions
  • Humans
  • RNA Viruses
  • Virus Diseases
  • Virus Latency
  • Virus Replication

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