Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus

Eike J Steinig; Patiyan Andersson; Simon R Harris; Derek S Sarovich; Anand Manoharan; Paul Coupland; Matthew Tg Holden; Julian Parkhill; Stephen D Bentley; D Ashley Robinson; Steven Yc Tong

doi:10.1186/s12864-015-1599-9

Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus

Eike J Steinig
, Patiyan Andersson
, Simon R Harris
, Derek S Sarovich
, Anand Manoharan
, Paul Coupland
, Matthew Tg Holden
, Julian Parkhill
, Stephen D Bentley
, D Ashley Robinson
, Steven Yc Tong

Research output: Contribution to journal › Article › peer-review

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-associated infection, but there is growing awareness of the emergence of multidrug-resistant lineages in community settings around the world. One such lineage is ST772-MRSA-V, which has disseminated globally and is increasingly prevalent in India. Here, we present the complete genome sequence of DAR4145, a strain of the ST772-MRSA-V lineage from India, and investigate its genomic characteristics in regards to antibiotic resistance and virulence factors.

Original language	English
Article number	388
Number of pages	10
Journal	BMC Genomics
Volume	16
DOIs	https://doi.org/10.1186/s12864-015-1599-9
Publication status	Published - 16 May 2015

Keywords

Staphylococcus aureas
MRSA
ST722
Antibiotic resistance
Mobile genetic elements
Complete genome
DAR4145
India

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steinig2015bmcgenomics388
© 2015 Steinig et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Steinig, E. J., Andersson, P., Harris, S. R., Sarovich, D. S., Manoharan, A., Coupland, P., Holden, M. T., Parkhill, J., Bentley, S. D., Robinson, D. A., & Tong, S. Y. (2015). Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus. BMC Genomics, 16, Article 388. https://doi.org/10.1186/s12864-015-1599-9

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title = "Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus",

abstract = "Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-associated infection, but there is growing awareness of the emergence of multidrug-resistant lineages in community settings around the world. One such lineage is ST772-MRSA-V, which has disseminated globally and is increasingly prevalent in India. Here, we present the complete genome sequence of DAR4145, a strain of the ST772-MRSA-V lineage from India, and investigate its genomic characteristics in regards to antibiotic resistance and virulence factors.",

keywords = "Staphylococcus aureas, MRSA, ST722, Antibiotic resistance, Mobile genetic elements, Complete genome, DAR4145, India",

author = "Steinig, \{Eike J\} and Patiyan Andersson and Harris, \{Simon R\} and Sarovich, \{Derek S\} and Anand Manoharan and Paul Coupland and Holden, \{Matthew Tg\} and Julian Parkhill and Bentley, \{Stephen D\} and Robinson, \{D Ashley\} and Tong, \{Steven Yc\}",

note = "YCT is an Australian National Health and Medical Research Council Career Development Fellow (1065736). DAR was supported in part by National Institutes of Health grant GM080602. SRH, PC, MTGH, JP and SDB were supported by Wellcome Trust grant 098051. ",

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doi = "10.1186/s12864-015-1599-9",

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AU - Steinig, Eike J

AU - Andersson, Patiyan

AU - Harris, Simon R

AU - Sarovich, Derek S

AU - Manoharan, Anand

AU - Coupland, Paul

AU - Holden, Matthew Tg

AU - Parkhill, Julian

AU - Bentley, Stephen D

AU - Robinson, D Ashley

AU - Tong, Steven Yc

N1 - YCT is an Australian National Health and Medical Research Council Career Development Fellow (1065736). DAR was supported in part by National Institutes of Health grant GM080602. SRH, PC, MTGH, JP and SDB were supported by Wellcome Trust grant 098051.

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AB - Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-associated infection, but there is growing awareness of the emergence of multidrug-resistant lineages in community settings around the world. One such lineage is ST772-MRSA-V, which has disseminated globally and is increasingly prevalent in India. Here, we present the complete genome sequence of DAR4145, a strain of the ST772-MRSA-V lineage from India, and investigate its genomic characteristics in regards to antibiotic resistance and virulence factors.

KW - Staphylococcus aureas

KW - MRSA

KW - ST722

KW - Antibiotic resistance

KW - Mobile genetic elements

KW - Complete genome

KW - DAR4145

KW - India

U2 - 10.1186/s12864-015-1599-9

DO - 10.1186/s12864-015-1599-9

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SN - 1471-2164

VL - 16

JO - BMC Genomics

JF - BMC Genomics

M1 - 388

ER -

Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus

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Keywords

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