Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus

Eike J Steinig, Patiyan Andersson, Simon R Harris, Derek S Sarovich, Anand Manoharan, Paul Coupland, Matthew Tg Holden, Julian Parkhill, Stephen D Bentley, D Ashley Robinson, Steven Yc Tong

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)
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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-associated infection, but there is growing awareness of the emergence of multidrug-resistant lineages in community settings around the world. One such lineage is ST772-MRSA-V, which has disseminated globally and is increasingly prevalent in India. Here, we present the complete genome sequence of DAR4145, a strain of the ST772-MRSA-V lineage from India, and investigate its genomic characteristics in regards to antibiotic resistance and virulence factors.

Original languageEnglish
Article number388
Number of pages10
JournalBMC Genomics
Volume16
DOIs
Publication statusPublished - 16 May 2015

Keywords

  • Staphylococcus aureas
  • MRSA
  • ST722
  • Antibiotic resistance
  • Mobile genetic elements
  • Complete genome
  • DAR4145
  • India

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