Simple (imidazol-2-ylidene)-Pd-acetate complexes as effective precatalysts for sterically hindered Suzuki-Miyaura couplings

R Singh, MS Viciu, N Kramareva, O Navarro, Steven Patrick Nolan

Research output: Contribution to journalArticlepeer-review

203 Citations (Scopus)

Abstract

A simplified synthesis of N-heterocyclic carbene (NHC)Pd-carboxylate complexes and their activity in Suzuki-Miyaura cross-coupling reactions are described. Coupling of sterically hindered aryl and activated alkyl chlorides bearing 6-hydrogens has been successfully achieved.

Original languageEnglish
Pages (from-to)1829-1832
Number of pages4
JournalOrganic Letters
Volume7
Issue number9
DOIs
Publication statusPublished - 28 Apr 2005

Keywords

  • CATALYZED AEROBIC OXIDATION
  • CROSS-COUPLINGS
  • ROOM-TEMPERATURE
  • ARYL CHLORIDES
  • ALKYL BROMIDES
  • ORGANOBORON COMPOUNDS
  • PHENYLBORONIC ACID
  • ARYLBORONIC ACIDS
  • MILD CONDITIONS
  • BOND FORMATION

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