TY - JOUR
T1 - Simple direct formation of self-assembled N-heterocyclic carbene monolayers on gold and their application in biosensing
AU - Crudden, Cathleen
AU - Horton, Hugh
AU - Narouz, Mina
AU - Li, Zhijun
AU - Smith, Christene
AU - Munro, Kim
AU - Baddeley, Christopher John
AU - Larrea, Christian Rodriguez
AU - Drevniok, Benedict
AU - Thanabalasingam, Bheeshmon
AU - Maclean, Alastair
AU - Zenkina, Olena
AU - Ebralidze, Iraklii
AU - She, Zhe
AU - Kraatz, Heinz-Bernhard
AU - Mosey, Nicholas
AU - Saunders, Lisa
AU - Yagi, Akiko
N1 - CRL acknowledges the Engineering and Physical Sciences Research Council (UK) for the funding of his PhD studentship (EP/M506631).
PY - 2016/9/2
Y1 - 2016/9/2
N2 - The formation of organic films on gold employing N-heterocyclic carbenes (NHCs) has been previously shown to be a useful strategy for generating stable organic films. However, NHCs or NHC precursors typically require inert atmosphere and harsh conditions for their generation and use. Herein we describe the use of benzimidazolium hydrogen carbonates as bench stable solid precursors for the preparation of NHC films in solution or by vapour-phase deposition from the solid state. The ability to prepare these films by vapour-phase deposition permitted the analysis of the films by a variety of surface science techniques, resulting in the first measurement of NHC desorption energy (158±10 kJ mol−1) and confirmation that the NHC sits upright on the surface. The use of these films in surface plasmon resonance-type biosensing is described, where they provide specific advantages versus traditional thiol-based films.
AB - The formation of organic films on gold employing N-heterocyclic carbenes (NHCs) has been previously shown to be a useful strategy for generating stable organic films. However, NHCs or NHC precursors typically require inert atmosphere and harsh conditions for their generation and use. Herein we describe the use of benzimidazolium hydrogen carbonates as bench stable solid precursors for the preparation of NHC films in solution or by vapour-phase deposition from the solid state. The ability to prepare these films by vapour-phase deposition permitted the analysis of the films by a variety of surface science techniques, resulting in the first measurement of NHC desorption energy (158±10 kJ mol−1) and confirmation that the NHC sits upright on the surface. The use of these films in surface plasmon resonance-type biosensing is described, where they provide specific advantages versus traditional thiol-based films.
UR - https://www.nature.com/articles/ncomms12654#Sec16
U2 - 10.1038/ncomms12654
DO - 10.1038/ncomms12654
M3 - Article
SN - 2041-1723
VL - 7
JO - Nature Communications
JF - Nature Communications
M1 - 12654
ER -