Seroprevalence of IgG antibodies against Bordetella pertussis in healthy individuals aged 4-24 years in Turkey

M. Cevik; U. Beyazova; A. L. Aral; A. Duyan Camurdan; S. Ozkan; F. Sahin; C. Aybay

doi:10.1111/j.1469-0691.2007.01926.x

Seroprevalence of IgG antibodies against Bordetella pertussis in healthy individuals aged 4-24 years in Turkey

M. Cevik, U. Beyazova, A. L. Aral, A. Duyan Camurdan^*, S. Ozkan, F. Sahin, C. Aybay

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The distribution of IgG antibodies to Bordetella pertussis was investigated in serum samples from 550 subjects, aged 4-24 years, to determine the optimal age for booster immunisation. Levels of antibody to B. pertussis antigens were determined using an ELISA that measures a mixture of pertussis toxin, filamentous haemagglutinin and lipopolysaccharide. Geometric mean titres of anti-pertussis antibodies in subjects aged 4-6 years were significantly lower than those in other age groups, which reflects waning immunity following vaccination. High positive titres in older children and adolescents suggested acquired B. pertussis infection, and booster doses at the ages of 7 and 15 years are therefore suggested.

Original language	English
Pages (from-to)	388-390
Number of pages	4
Journal	Clinical Microbiology and Infection
Volume	14
Issue number	4
DOIs	https://doi.org/10.1111/j.1469-0691.2007.01926.x
Publication status	Published - Apr 2008

Keywords

antibodies
Bordetella pertussis
ELISA
immunity
seroprevalence
vaccination recommendations
SEROEPIDEMIOLOGY
AUSTRALIA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1469-0691.2007.01926.x

Cite this

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title = "Seroprevalence of IgG antibodies against Bordetella pertussis in healthy individuals aged 4-24 years in Turkey",

abstract = "The distribution of IgG antibodies to Bordetella pertussis was investigated in serum samples from 550 subjects, aged 4-24 years, to determine the optimal age for booster immunisation. Levels of antibody to B. pertussis antigens were determined using an ELISA that measures a mixture of pertussis toxin, filamentous haemagglutinin and lipopolysaccharide. Geometric mean titres of anti-pertussis antibodies in subjects aged 4-6 years were significantly lower than those in other age groups, which reflects waning immunity following vaccination. High positive titres in older children and adolescents suggested acquired B. pertussis infection, and booster doses at the ages of 7 and 15 years are therefore suggested.",

keywords = "antibodies, Bordetella pertussis, ELISA, immunity, seroprevalence, vaccination recommendations, SEROEPIDEMIOLOGY, AUSTRALIA",

author = "M. Cevik and U. Beyazova and Aral, {A. L.} and Camurdan, {A. Duyan} and S. Ozkan and F. Sahin and C. Aybay",

year = "2008",

month = apr,

doi = "10.1111/j.1469-0691.2007.01926.x",

language = "English",

volume = "14",

pages = "388--390",

journal = "Clinical Microbiology and Infection",

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publisher = "Blackwell",

number = "4",

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TY - JOUR

T1 - Seroprevalence of IgG antibodies against Bordetella pertussis in healthy individuals aged 4-24 years in Turkey

AU - Cevik, M.

AU - Beyazova, U.

AU - Aral, A. L.

AU - Camurdan, A. Duyan

AU - Ozkan, S.

AU - Sahin, F.

AU - Aybay, C.

PY - 2008/4

Y1 - 2008/4

N2 - The distribution of IgG antibodies to Bordetella pertussis was investigated in serum samples from 550 subjects, aged 4-24 years, to determine the optimal age for booster immunisation. Levels of antibody to B. pertussis antigens were determined using an ELISA that measures a mixture of pertussis toxin, filamentous haemagglutinin and lipopolysaccharide. Geometric mean titres of anti-pertussis antibodies in subjects aged 4-6 years were significantly lower than those in other age groups, which reflects waning immunity following vaccination. High positive titres in older children and adolescents suggested acquired B. pertussis infection, and booster doses at the ages of 7 and 15 years are therefore suggested.

AB - The distribution of IgG antibodies to Bordetella pertussis was investigated in serum samples from 550 subjects, aged 4-24 years, to determine the optimal age for booster immunisation. Levels of antibody to B. pertussis antigens were determined using an ELISA that measures a mixture of pertussis toxin, filamentous haemagglutinin and lipopolysaccharide. Geometric mean titres of anti-pertussis antibodies in subjects aged 4-6 years were significantly lower than those in other age groups, which reflects waning immunity following vaccination. High positive titres in older children and adolescents suggested acquired B. pertussis infection, and booster doses at the ages of 7 and 15 years are therefore suggested.

KW - antibodies

KW - Bordetella pertussis

KW - ELISA

KW - immunity

KW - seroprevalence

KW - vaccination recommendations

KW - SEROEPIDEMIOLOGY

KW - AUSTRALIA

U2 - 10.1111/j.1469-0691.2007.01926.x

DO - 10.1111/j.1469-0691.2007.01926.x

M3 - Article

SN - 1198-743X

VL - 14

SP - 388

EP - 390

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 4

ER -

Seroprevalence of IgG antibodies against Bordetella pertussis in healthy individuals aged 4-24 years in Turkey

Abstract

Keywords

UN SDGs

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