Serological profiling of group A Streptococcus infections in acute rheumatic fever

Natalie Lorenz; Timothy K C Ho; Reuben McGregor; Mark R Davies; Deborah A Williamson; Jason K Gurney; Pierre R Smeesters; Michael G Baker; Nicole J Moreland

doi:10.1093/cid/ciab180

Serological profiling of group A Streptococcus infections in acute rheumatic fever

Natalie Lorenz, Timothy K C Ho, Reuben McGregor, Mark R Davies, Deborah A Williamson, Jason K Gurney, Pierre R Smeesters, Michael G Baker, Nicole J Moreland^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.

Original language	English
Pages (from-to)	2322-2325
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	73
Issue number	12
Early online date	30 Apr 2021
DOIs	https://doi.org/10.1093/cid/ciab180
Publication status	Published - 15 Dec 2021

Keywords

Antigens, Bacterial
Humans
Rheumatic Fever/complications
Streptococcal Infections/complications
Streptococcus pyogenes

Access to Document

10.1093/cid/ciab180

Handle.net

Persistent link

Cite this

@article{3a8c4586513549838cd0559cb5b35dd1,

title = "Serological profiling of group A Streptococcus infections in acute rheumatic fever",

abstract = "Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.",

keywords = "Antigens, Bacterial, Humans, Rheumatic Fever/complications, Streptococcal Infections/complications, Streptococcus pyogenes",

author = "Natalie Lorenz and Ho, \{Timothy K C\} and Reuben McGregor and Davies, \{Mark R\} and Williamson, \{Deborah A\} and Gurney, \{Jason K\} and Smeesters, \{Pierre R\} and Baker, \{Michael G\} and Moreland, \{Nicole J\}",

note = "This work was supported by the Auckland Medical Research Foundation and the Maurice Wilkins Centre for Biodiscovery. The Rheumatic Fever Risk Factors study, from which samples were obtained, was funded by the Heath Research Council of New Zealand (HRC) Rheumatic Fever Research Partnership (Ministry of Health, Te Puni Kōkiri, Cure Kids, Heart Foundation, and HRC).",

year = "2021",

month = dec,

day = "15",

doi = "10.1093/cid/ciab180",

language = "English",

volume = "73",

pages = "2322--2325",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "12",

}

TY - JOUR

T1 - Serological profiling of group A Streptococcus infections in acute rheumatic fever

AU - Lorenz, Natalie

AU - Ho, Timothy K C

AU - McGregor, Reuben

AU - Davies, Mark R

AU - Williamson, Deborah A

AU - Gurney, Jason K

AU - Smeesters, Pierre R

AU - Baker, Michael G

AU - Moreland, Nicole J

N1 - This work was supported by the Auckland Medical Research Foundation and the Maurice Wilkins Centre for Biodiscovery. The Rheumatic Fever Risk Factors study, from which samples were obtained, was funded by the Heath Research Council of New Zealand (HRC) Rheumatic Fever Research Partnership (Ministry of Health, Te Puni Kōkiri, Cure Kids, Heart Foundation, and HRC).

PY - 2021/12/15

Y1 - 2021/12/15

N2 - Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.

AB - Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.

KW - Antigens, Bacterial

KW - Humans

KW - Rheumatic Fever/complications

KW - Streptococcal Infections/complications

KW - Streptococcus pyogenes

UR - https://www.scopus.com/pages/publications/85111565774

U2 - 10.1093/cid/ciab180

DO - 10.1093/cid/ciab180

M3 - Article

C2 - 33639619

SN - 1058-4838

VL - 73

SP - 2322

EP - 2325

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 12

ER -

Serological profiling of group A Streptococcus infections in acute rheumatic fever

Abstract

Keywords

Access to Document

Handle.net

Other files and links

Fingerprint

Cite this